Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | GLA | P06280 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | BCL2 | P10415 | 10/20 | 0.69 |
| ▸ | BECN1 | Q14457 | 10/20 | 0.69 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.67 |
| ▸ | ITGAV | P06756 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23268960 | 0.86 | PKM (0.80) | PKMALDH1A1LMNABCL2BECN1 | |
| SCHEMBL23268986 | 0.84 | PKM (1.00) | PKMALDH1A1KDM4ELMNAGAA | |
| SCHEMBL23268914 | 0.83 | BCL2 (0.86) | PKMALDH1A1KDM4EGAAHTT | |
| SCHEMBL14133972 | 0.82 | ALDH1A1 (0.71) | PKMALDH1A1KDM4ELMNAGLA | |
| SCHEMBL14133627 | 0.82 | BCL2 (0.72) | PKMALDH1A1KDM4ELMNAGLA | |
| SCHEMBL14133808 | 0.81 | ALDH1A1 (0.70) | PKMALDH1A1KDM4ELMNAGLA | |
| SCHEMBL23269372 | 0.81 | BCL2 (1.00) | PKMALDH1A1BCL2BECN1MEN1 | |
| SCHEMBL14133989 | 0.81 | KDM4E (0.69) | PKMALDH1A1KDM4ELMNAGLA | |
| SCHEMBL23269265 | 0.81 | BCL2 (1.00) | PKMALDH1A1BCL2BECN1ITGB3 | |
| SCHEMBL23269361 | 0.81 | BCL2 (1.00) | PKMALDH1A1KDM4ELMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203020-A1 | Small molecule inducers of autophagy | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-06-29 | — | — | US | disclosed |
| US-20230203020-A1 | Small molecule inducers of autophagy | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-06-29 | — | — | US | disclosed |
| US-11325898-B2 | Small molecule inducers of autophagy | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-05-10 | — | — | US | disclosed |
| US-20210115024-A1 | Small molecule inducers of autophagy | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11325898-B2 | Small molecule inducers of autophagy | BECN1, SQSTM1, MAP1LC3A | PKM 4064/4885ALDH1A1 4649/4885KDM4E 2509/4885 |
| US-20210115024-A1 | Small molecule inducers of autophagy | BECN1, SQSTM1, MAP1LC3A | PKM 4064/4885ALDH1A1 4649/4885KDM4E 2509/4885 |
| US-20230203020-A1 | Small molecule inducers of autophagy | BECN1, SQSTM1, MAP1LC3A | PKM 4064/4885ALDH1A1 4649/4885KDM4E 2509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.