SCHEMBL2327490

SCHEMBL2327490

Nc1ccc(-c2c(-c3ccccc3)c(-c3ccccc3)c(N)c(-c3ccccc3)c2-c2ccccc2)c(O)c1O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
HSD17B10 Q99714 3/20 0.38
HDAC4 P56524 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
MAPT P10636 3/20 0.36
HPGD P15428 3/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
KDM4E B2RXH2 1/20 0.36
USP2 O75604 1/20 0.36
LMNA P02545 1/20 0.36
HSP90AA1 P07900 1/20 0.36
GAA P10253 1/20 0.36
ALOX15 P16050 1/20 0.36
ALOX12 P18054 1/20 0.36
HTT P42858 1/20 0.36
PDE4B Q07343 3/20 0.35
PDE4A P27815 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8724544 0.84 HSD17B10 (0.52) ALDH1A1HSD17B10HDAC4HDAC2HDAC8
SCHEMBL5595212 0.79 ALDH1A1 (0.46) ALDH1A1HSD17B10HDAC4HDAC2HDAC8
SCHEMBL8853081 0.78 ALDH1A1 (0.50) ALDH1A1HSD17B10HDAC4HDAC2HDAC8
SCHEMBL21248552 0.78 PDE4A (0.43) ALDH1A1HSD17B10HDAC4HDAC2HDAC8
SCHEMBL9424850 0.77 ALDH1A1 (0.34) ALDH1A1HSD17B10HDAC4HDAC2HDAC8
SCHEMBL5030574 0.77 HSD17B10 (0.48) ALDH1A1HSD17B10MAPTHPGDMEN1
SCHEMBL9329612 0.76 ALDH1A1 (0.36) ALDH1A1HSD17B10MAPTHPGDMEN1
SCHEMBL4372489 0.76 ALDH1A1 (0.48) ALDH1A1HSD17B10HDAC4HDAC2HDAC8
SCHEMBL28318563 0.76 HSD17B10 (0.43) ALDH1A1HSD17B10HDAC4HDAC2HDAC8
SCHEMBL1899394 0.75 HSD17B10 (0.46) ALDH1A1HSD17B10MAPTHPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0550161-B1 Single layer photoreceptor XEROX CORP (US) 2000-06-07 EP claimed
US-5336577-A Single layer photoreceptor XEROX CORPORATION (US) 1994-08-09 US claimed
US-8779203-B2 Continuous production of arylamine XEROX CORPORATION (US) 2014-07-15 US disclosed
US-20130046110-A1 Continuous production of arylamine XEROX CORPORATION (US) 2013-02-21 US disclosed
US-8211603-B2 Photoreceptor XEROX CORPORATION (US) 2012-07-03 US disclosed
US-8034518-B2 Photoreceptor XEROX CORPORATION (US) 2011-10-11 US disclosed
EP-1887428-B1 Photoreceptor XEROX CORP (US) 2011-08-17 EP disclosed
US-7740997-B2 Photoreceptor including multi-block polymeric charge transport material at least partially embedded within a carbon nanotube material XEROX CORPORATION (US) 2010-06-22 US disclosed
US-7635548-B2 Photoreceptor XEROX CORPORATION (US) 2009-12-22 US disclosed
US-7588872-B2 Electrographic imaging using a single active layer, also called a photogenerating layer, that includes carbon nanotubes (0.1-50 nm diameter, 0.01-500mm length) and performs both charge generating and hole transport functions; toners; quality; high speed; durability; copiers; duplication; printers XEROX CORPORATION (US) 2009-09-15 US disclosed
US-20090029276-A1 PHOTORECEPTOR XEROX CORPORATION (US) 2009-01-29 US disclosed
US-20080038648-A1 PHOTORECEPTOR XEROX CORPORATION (US) 2008-02-14 US disclosed
US-20080038650-A1 PHOTORECEPTOR XEROX CORPORATION (US) 2008-02-14 US disclosed
EP-1887426-A1 Photoreceptor Xerox Corporation (US) 2008-02-13 EP disclosed
EP-1887428-A2 Photoreceptor Xerox Corporation (US) 2008-02-13 EP disclosed
US-7163771-B2 Imaging members XEROX CORPORATION (US) 2007-01-16 US disclosed
CN-1776535-A Toner process XEROX CORP (US) 2006-05-24 CN disclosed
US-20050287453-A1 A photoconductive imaging member containing a supporting substrate, and a single layer comprised of a photogenerator component, a charge transport component, an electron transport component (alkylalcohol derivative) , and a polymer binder. XEROX CORPORATION 2005-12-29 US disclosed
EP-0550161-B1 Single layer photoreceptor XEROX CORP (US) 2000-06-07 EP disclosed
US-5336577-A Single layer photoreceptor XEROX CORPORATION (US) 1994-08-09 US disclosed