Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 14/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 12/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | KDM1A | O60341 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | YES1 | P07947 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6426524 | 0.89 | ADORA2A (0.58) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL4285483 | 0.78 | MEN1 (0.54) | MEN1KMT2AKDM1APOLBMAPT | |
| SCHEMBL1697135 | 0.77 | ADORA2B (0.64) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL1945245 | 0.76 | ADORA2B (1.00) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL5685833 | 0.76 | ADORA2B (0.60) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL243045 | 0.76 | ADORA2B (1.00) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL22800983 | 0.74 | ALDH1A1 (0.66) | MEN1KMT2AKDM1APOLBKDM4E | |
| SCHEMBL13995583 | 0.73 | ADORA2B (0.75) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4291739 | 0.72 | KDM1A (0.60) | MEN1KMT2AKDM1APOLBMAPT | |
| SCHEMBL5195433 | 0.72 | ADORA2B (0.70) | ADORA2BADORA1ADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444233-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | GILEAD PALO ALTO INC (US) | 2011-08-17 | — | — | EP | disclosed |