Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | KDM1A | O60341 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | YES1 | P07947 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4291739 | 0.95 | KDM1A (0.60) | MEN1KMT2AKDM1AALDH1A1KDM4E | |
| SCHEMBL4284310 | 0.92 | KDM1A (0.54) | MEN1KMT2AKDM1AALDH1A1KDM4E | |
| SCHEMBL4016883 | 0.80 | TPH1 (0.44) | MEN1KMT2AKDM1AALDH1A1KDM4E | |
| SCHEMBL2327640 | 0.78 | ADORA2B (0.62) | MEN1KMT2AKDM1AALDH1A1KDM4E | |
| SCHEMBL4019166 | 0.78 | NOD1 (0.37) | MEN1KMT2AKDM1ANOD1 | |
| SCHEMBL4018480 | 0.77 | TPH1 (0.50) | MEN1KMT2AKDM1AALDH1A1KDM4E | |
| SCHEMBL5509419 | 0.77 | ADORA3 (0.44) | MEN1KMT2AKDM1AALDH1A1KDM4E | |
| SCHEMBL4016181 | 0.73 | MEN1 (0.42) | MEN1KMT2AKDM1AALDH1A1HTT | |
| SCHEMBL5687959 | 0.71 | ADORA2B (0.63) | MEN1KMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4014400 | 0.71 | ADORA2A (0.41) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009157938-A1 | A2B ADENOSINE RECEPTOR ANTAGONISTS FOR TREATING CANCER | CV THERAPEUTICS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |