Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.85 |
| ▸ | RAB9A | P51151 | 2/20 | 0.85 |
| ▸ | MAPT | P10636 | 5/20 | 0.79 |
| ▸ | POLB | P06746 | 3/20 | 0.78 |
| ▸ | MEN1 | O00255 | 3/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.78 |
| ▸ | PLEC | Q15149 | 1/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2331162 | 0.91 | MAPT (0.85) | NPC1RAB9AMAPTPOLBMEN1 | |
| SCHEMBL14119286 | 0.88 | MAPT (1.00) | NPC1RAB9AMAPTPOLBMEN1 | |
| SCHEMBL3880564 | 0.84 | MAPT (0.77) | NPC1RAB9AMAPTPOLBMEN1 | |
| SCHEMBL3945435 | 0.83 | MAPT (0.72) | NPC1RAB9AMAPTPOLBMEN1 | |
| SCHEMBL3278007 | 0.83 | ALDH1A1 (0.73) | NPC1RAB9AMAPTPOLBMEN1 | |
| SCHEMBL4518987 | 0.82 | MAPT (0.73) | NPC1RAB9AMAPTPOLBMEN1 | |
| SCHEMBL3884846 | 0.79 | MAPT (0.68) | NPC1RAB9AMAPTPOLBMEN1 | |
| SCHEMBL2361446 | 0.77 | MAPT (0.66) | NPC1RAB9AMAPTPOLBMEN1 | |
| SCHEMBL4389144 | 0.75 | MAOA (1.00) | NPC1RAB9AMAPTTP53MAOA | |
| SCHEMBL3952682 | 0.70 | MAPT (0.51) | NPC1RAB9AMAPTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160067257-A1 | SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY | THE WISTAR INSTITUTE (US) | 2016-03-10 | — | — | US | disclosed |
| US-9234230-B2 | Screening method and compounds for modulating telomerase activity | THE WISTAR INSTITUTE (US) | 2016-01-12 | — | — | US | disclosed |
| US-8377992-B2 | TRBD-binding effectors and methods for using the same to modulate telomerase activity | THE WISTAR INSTITUTE (US) | 2013-02-19 | — | — | US | disclosed |
| US-20120309759-A1 | Screening Method and Compounds for Modulating Telomerase Activity | THE WISTAR INSTITUTE (US) | 2012-12-06 | — | — | US | disclosed |
| WO-2011097600-A1 | SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY | THE WISTAR INSTITUTE (US) | 2011-08-11 | — | — | WO | disclosed |
| US-20100160260-A1 | TRBD-Binding Effectors and Methods for Using the Same to Modulate Telomerase Activity | THE WISTAR INSTITUTE | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309759-A1 | Screening Method and Compounds for Modulating Telomerase Activity | TERT, TERB1, TERF2 | NPC1 3713/4885RAB9A 3522/4885MAPT 2733/4885 |
| US-20160067257-A1 | SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY | TERT, TERB1, TERF2 | NPC1 3713/4885RAB9A 3522/4885MAPT 2733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.