Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.62 |
| ▸ | HTR7 | P34969 | 3/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.56 |
| ▸ | HTR3B | O95264 | 3/20 | 0.56 |
| ▸ | HTR3A | P46098 | 3/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HTR5A | P47898 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | NCF1 | P14598 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29446041 | 1.00 | HTR6 (0.62) | HTR6ADRB1HTR7HTR3EHTR3B | |
| SCHEMBL10677139 | 1.00 | HTR6 (0.62) | HTR6ADRB1HTR7HTR3EHTR3B | |
| Piperazine SCHEMBL28234322 | 0.98 | HTR6 (0.61) | HTR6ADRB1HTR7HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL27845681 | 0.98 | HTR6 (0.61) | HTR6ADRB1HTR7HTR3EHTR3B | |
| Ethane SCHEMBL11509421 | 0.96 | ADRB1 (0.61) | HTR6ADRB1HTR7HTR3EHTR3B | |
| SCHEMBL8309915 | 0.89 | HTR6 (0.56) | HTR6ADRB1HTR7HTR3EHTR3B | |
| SCHEMBL28235242 | 0.84 | MGLL (0.46) | HTR6ADRB1HTR1ACYP1A2TSHR | |
| SCHEMBL27926749 | 0.84 | MGLL (0.46) | HTR6ADRB1HTR1ACYP1A2TSHR | |
| SCHEMBL15834279 | 0.84 | ADRB1 (0.75) | HTR6ADRB1HTR7HTR3EHTR3B | |
| SCHEMBL7582175 | 0.84 | HTR6 (0.54) | HTR6ADRB1HTR7HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117024376-A | Preparation method of hydrobromic acid voltammetric acid duloxetine | 寿光富康制药有限公司 | 2023-11-10 | — | — | CN | claimed |
| CN-109496211-B | Piperazine derivative for resisting candida albicans as well as preparation method and application thereof | 华南农业大学 | 2022-03-22 | — | — | CN | claimed |
| CN-104829558-B | Preparation method of diaryl thioether amine compound | 江苏豪森药业集团有限公司 | 2020-03-03 | — | — | CN | claimed |
| CN-109438391-A | A kind of preparation method of hydrobromic acid Vortioxetine impurity | 合肥创新医药技术有限公司 | 2019-03-08 | — | — | CN | claimed |
| CN-108314661-A | A kind of bis- (2- bromophenyls of 1,4-）The preparation method of piperazine | 安徽源久源科技有限公司 | 2018-07-24 | — | — | CN | claimed |
| CN-118221612-A | Preparation method of l- [2- (2, 4-dimethylbenzenesulfide) -phenyl ] piperazine halogen acid salt | 浙江华海药业股份有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-118221612-A | Preparation method of l- [2- (2, 4-dimethylbenzenesulfide) -phenyl ] piperazine halogen acid salt | 浙江华海药业股份有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-117050035-B | Preparation method of hydrobromic acid voltammetric acid duloxetine | 山东锐顺药业有限公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-117050035-A | Preparation method of hydrobromic acid voltammetric acid duloxetine | 山东锐顺药业有限公司 | 2023-11-14 | — | — | CN | disclosed |
| CN-117024376-A | Preparation method of hydrobromic acid voltammetric acid duloxetine | 寿光富康制药有限公司 | 2023-11-10 | — | — | CN | disclosed |
| CN-116444461-A | Dibenzylbutane lignan LCA derivative and application thereof | 中国人民解放军海军军医大学 | 2023-07-18 | — | — | CN | disclosed |
| CN-109912514-B | (2-heteroarylaminophenyl) nitrogen heterocyclic derivative and application thereof | 广东东阳光药业有限公司 | 2022-11-18 | — | — | CN | disclosed |
| WO-2001014355-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR UTILIZATION AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-01 | — | — | WO | disclosed |
| EP-1075469-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Samjin Pharmaceutical Co., Ltd. (KR) | 2001-02-14 | — | — | EP | disclosed |
| WO-2000052001-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2000-09-08 | — | — | WO | disclosed |
| US-5780472-A | ANTITUMOR AGENTS | SAMJIN PHARMACEUTICAZL CO., LTD. (KR) | 1998-07-14 | — | — | US | disclosed |
| EP-0749425-A1 | NEW PIPERAZINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME | SAMJIN PHARM. CO., LTD. (KR) | 1996-12-27 | — | — | EP | disclosed |
| WO-1996021648-A1 | NEW PIPERAZINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 1996-07-18 | — | — | WO | disclosed |
| CN-86104256-A | 1, the preparation method of 8-bridging 4-quinolone-3-carboxylic-acid | — | 1987-03-18 | — | — | CN | disclosed |
| US-4159331-A | Antihypertensive 4-aminoquinolines | THE UPJOHN COMPANY (US) | 1979-06-26 | — | — | US | disclosed |