Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 4/20 | 0.50 |
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | HTR3A | P46098 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR5A | P47898 | 2/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.50 |
| ▸ | HTR3B | O95264 | 2/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL8313245 | 0.91 | HTR6 (0.55) | HTR6ADRB1HTR1AHTR7HTR3A | |
| SCHEMBL29446041 | 0.89 | HTR6 (0.62) | HTR6ADRB1HTR1AHTR7HTR3A | |
| SCHEMBL10677139 | 0.89 | HTR6 (0.62) | HTR6ADRB1HTR1AHTR7HTR3A | |
| SCHEMBL232830 | 0.89 | HTR6 (0.62) | HTR6ADRB1HTR1AHTR7HTR3A | |
| Hydrochloric Acid SCHEMBL27845681 | 0.87 | HTR6 (0.61) | HTR6ADRB1HTR1AHTR7HTR3A | |
| Piperazine SCHEMBL28234322 | 0.87 | HTR6 (0.61) | HTR6ADRB1HTR1AHTR7HTR3A | |
| Ethane SCHEMBL11509421 | 0.85 | ADRB1 (0.61) | HTR6ADRB1HTR1AHTR7HTR3A | |
| SCHEMBL11087855 | 0.79 | ADRA2C (0.53) | HTR6HTR1AHTR2ANCF1TSHR | |
| SCHEMBL15834279 | 0.78 | ADRB1 (0.75) | HTR6ADRB1HTR1AHTR7HTR3A | |
| SCHEMBL7582175 | 0.78 | HTR6 (0.54) | HTR6ADRB1HTR1AHTR7HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998414-A | PSYCHOLOGICAL DISORDERS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0929537-A1 | TROPONYL PIPERAZINES AS SELECTIVE DOPAMINE D4 RECEPTOR LIGANDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998007711-A1 | TROPONYL PIPERAZINES AS SELECTIVE DOPAMINE D4 RECEPTOR LIGANDS | HOECHST MARION ROUSSEL, INC. (US) | 1998-02-26 | — | — | WO | disclosed |