Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15306513 | 0.90 | ADAM17 (0.45) | ALDH1A1TDP1CYP3A4TSHRMAPK1 | |
| SCHEMBL297404 | 0.90 | ADAM17 (0.45) | ALDH1A1TDP1CYP3A4TSHRMAPK1 | |
| SCHEMBL23274871 | 0.84 | EPHX2 (0.44) | ALDH1A1CYP3A4LMNAEPHX2OPRM1 | |
| SCHEMBL296907 | 0.81 | GRM2 (0.47) | ALDH1A1TDP1BCHEEPHX2OPRM1 | |
| SCHEMBL14409083 | 0.81 | GRM2 (0.47) | ALDH1A1TDP1BCHEEPHX2OPRM1 | |
| SCHEMBL871442 | 0.76 | ADAM17 (0.46) | ALDH1A1TDP1CYP3A4TSHRMAPK1 | |
| Ethoxycarbonyl Group SCHEMBL27936134 | 0.75 | EPHX2 (0.36) | L3MBTL1BCHEEPHX2OPRM1OPRL1 | |
| SCHEMBL15927866 | 0.75 | ADAM17 (0.46) | ALDH1A1TDP1CYP3A4TSHRMAPK1 | |
| SCHEMBL8050802 | 0.74 | ADAM17 (0.43) | ALDH1A1TDP1CYP3A4TSHRMAPK1 | |
| SCHEMBL12277199 | 0.74 | LMNA (0.46) | ALDH1A1TDP1CYP3A4TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021081272-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2021-04-29 | — | — | WO | disclosed |