Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.68 |
| ▸ | TP53 | P04637 | 5/20 | 0.68 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.67 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.67 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | CASP3 | P42574 | 2/20 | 0.64 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.64 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | CHUK | O15111 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23288072 | 0.88 | ALDH1A1 (0.74) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL13606307 | 0.84 | CASP3 (0.77) | SMN1; SMN2TP53CASP3SENP8SENP7 | |
| SCHEMBL3796996 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL1422890 | 0.81 | CHRNB2 (1.00) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL1423193 | 0.80 | CHRNB2 (0.83) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL27789200 | 0.79 | SMN1; SMN2 (0.62) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL13889828 | 0.79 | CASP3 (1.00) | SMN1; SMN2TP53CASP3SENP8SENP7 | |
| SCHEMBL8051460 | 0.79 | SMN1; SMN2 (0.77) | SMN1; SMN2TP53CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL30070521 | 0.79 | ALDH1A1 (0.60) | SMN1; SMN2TP53ALDH1A1MAPTRAB9A | |
| SCHEMBL1155160 | 0.79 | ALDH1A1 (0.60) | SMN1; SMN2TP53ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021081337-A1 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE | CASE WESTERN RESERVE UNIVERSITY (US) | 2021-04-29 | — | — | WO | disclosed |