Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2332116 | 1.00 | MEN1 (0.43) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2332508 | 0.91 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2332522 | 0.91 | KMT2A (0.42) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2329497 | 0.89 | CYP1A2 (0.39) | MEN1KMT2AALDH1A1LMNAPOLB | |
| SCHEMBL2328729 | 0.89 | CYP1A2 (0.39) | MEN1KMT2AALDH1A1LMNAPOLB | |
| SCHEMBL3292156 | 0.82 | TAS1R3 (0.46) | MEN1KMT2ATAS1R3TAS1R1LMNA | |
| SCHEMBL1753950 | 0.82 | TAS1R3 (0.46) | MEN1KMT2ATAS1R3TAS1R1LMNA | |
| SCHEMBL1753973 | 0.82 | TAS1R3 (0.46) | MEN1KMT2ATAS1R3TAS1R1LMNA | |
| SCHEMBL2330442 | 0.80 | CYP1A2 (0.36) | MEN1KMT2APOLBRAB9ANPC1 | |
| SCHEMBL2330077 | 0.80 | SMN1; SMN2 (0.47) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222631-B1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER (US) | 2011-08-17 | — | — | EP | claimed |