Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2332116 | 0.91 | MEN1 (0.43) | KMT2AMEN1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2329485 | 0.91 | MEN1 (0.43) | KMT2AMEN1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2328729 | 0.88 | CYP1A2 (0.39) | KMT2AMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2329497 | 0.88 | CYP1A2 (0.39) | KMT2AMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2330077 | 0.84 | SMN1; SMN2 (0.47) | KMT2AMEN1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2332508 | 0.82 | MEN1 (0.41) | KMT2AMEN1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2333876 | 0.80 | TRPV1 (0.45) | KMT2AHPGDTSHRCYP1A2CYP3A4 | |
| SCHEMBL1754350 | 0.80 | TAS1R3 (0.44) | KMT2AMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2330442 | 0.79 | CYP1A2 (0.36) | KMT2AMEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL2108087 | 0.74 | CYP1A2 (0.38) | KMT2AMEN1SMN1; SMN2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222631-B1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER (US) | 2011-08-17 | — | — | EP | claimed |