Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2329497 | 0.91 | CYP1A2 (0.39) | CYP1A2CYP3A4CYP2C19TDP1KMT2A | |
| SCHEMBL2328729 | 0.91 | CYP1A2 (0.39) | CYP1A2CYP3A4CYP2C19TDP1KMT2A | |
| SCHEMBL2332508 | 0.90 | MEN1 (0.41) | PDE2AKMT2AMEN1POLBNPC1 | |
| SCHEMBL2106773 | 0.81 | MEN1 (0.39) | CYP1A2CYP2C19TDP1PDE2AKMT2A | |
| SCHEMBL2329485 | 0.80 | MEN1 (0.43) | KMT2AMEN1POLBNPC1RAB9A | |
| SCHEMBL2332116 | 0.80 | MEN1 (0.43) | KMT2AMEN1POLBNPC1RAB9A | |
| SCHEMBL2326235 | 0.80 | ADORA2A (0.34) | PDE2A | |
| SCHEMBL1841391 | 0.79 | CCR1 (0.39) | KMT2AMEN1RAB9ACCR1 | |
| SCHEMBL2332522 | 0.79 | KMT2A (0.42) | CYP1A2CYP3A4CYP2C19KMT2AMEN1 | |
| SCHEMBL1842345 | 0.79 | ROCK2 (0.35) | KMT2AMEN1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222631-B1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER (US) | 2011-08-17 | — | — | EP | claimed |