SCHEMBL2329574

SCHEMBL2329574

Cc1cc(-c2ccnc(Nc3ccccc3)n2)ccn1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 3/20 0.61
PRKCD Q05655 2/20 0.61
EGFR P00533 1/20 0.61
PRKCA P17252 1/20 0.61
SMG1 Q96Q15 1/20 0.57
CAMK2D Q13557 3/20 0.57
JAK2 O60674 1/20 0.56
JAK3 P52333 1/20 0.56
CDK2 P24941 3/20 0.56
CDK4 P11802 2/20 0.56
PLK1 P53350 3/20 0.55
CCNE1 P24864 1/20 0.54
PIK3C3 Q8NEB9 1/20 0.54
BCR P11274 2/20 0.53
PIK3CA P42336 1/20 0.53
PIK3CG P48736 1/20 0.53
KDR P35968 1/20 0.53
PTK2 Q05397 1/20 0.53
SRC P12931 1/20 0.52
GSK3B P49841 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2331086 0.87 PIK3CG (0.70) ABL1SMG1CAMK2DCDK2PLK1
SCHEMBL2322043 0.87 PIK3CG (0.70) ABL1SMG1CAMK2DCDK2PLK1
Hydrochloric Acid SCHEMBL16496538 0.86 PIK3CG (0.69) ABL1SMG1CAMK2DCDK2PLK1
SCHEMBL2328157 0.85 CAMK2D (0.70) ABL1PRKCDPRKCASMG1CAMK2D
SCHEMBL27444158 0.84 ABL1 (0.70) ABL1PRKCDEGFRPRKCASMG1
SCHEMBL14253908 0.84 ABL1 (0.59) ABL1PRKCDEGFRPRKCASMG1
SCHEMBL27116599 0.84 ABL1 (0.62) ABL1PRKCDEGFRPRKCASMG1
SCHEMBL20776156 0.83 ABL1 (0.56) ABL1PRKCDEGFRPRKCASMG1
SCHEMBL2324992 0.83 PIK3CG (0.76) ABL1EGFRPRKCASMG1CAMK2D
SCHEMBL1593016 0.82 PRKCD (0.79) ABL1PRKCDEGFRPRKCACAMK2D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110294810-A1 SUBSTITUTED (PYRIDYL)-AZINYLAMINE DERIVATIVES AS PLANT PROTECTION AGENTS BAYER CROPSCIENCE AG (DE) 2011-12-01 US claimed
CN-102216286-A Substituted (pyridyl)-azinylamine derivatives as plant protection agents BAYER CROPSCIENCE SA 2011-10-12 CN claimed
US-20110294810-A1 SUBSTITUTED (PYRIDYL)-AZINYLAMINE DERIVATIVES AS PLANT PROTECTION AGENTS BAYER CROPSCIENCE AG (DE) 2011-12-01 US disclosed
CN-102216286-A Substituted (pyridyl)-azinylamine derivatives as plant protection agents BAYER CROPSCIENCE SA 2011-10-12 CN disclosed
EP-2356102-A1 SUBSTITUTED (PYRIDYL)-AZINYLAMINE DERIVATIVES AS PLANT PROTECTION AGENTS Bayer CropScience AG (DE) 2011-08-17 EP disclosed
WO-2010055114-A1 SUBSTITUTED (PYRIDYL)-AZINYLAMINE DERIVATIVES AS PLANT PROTECTION AGENTS BAYER CROPSCIENCE SA (FR) 2010-05-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110294810-A1 SUBSTITUTED (PYRIDYL)-AZINYLAMINE DERIVATIVES AS PLANT PROTECTION AGENTS PRXL2A, AZI2, PIR ABL1 801/4885PRKCD 4098/4885EGFR 4246/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.