Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16341351 | 0.91 | MMP2 (0.41) | MMP2HSD11B1MCHR1HSD17B10EPHX2 | |
| SCHEMBL18440285 | 0.80 | EPHX2 (0.52) | HSD11B1HSD17B10EPHX2CYP2C8 | |
| SCHEMBL3538194 | 0.80 | EPHX2 (0.41) | HSD11B1HSD17B10EPHX2CYP2C8CYP2C9 | |
| SCHEMBL2324142 | 0.78 | SLC6A3 (0.39) | ICMT | |
| SCHEMBL13364057 | 0.77 | ALDH1A1 (0.40) | MMP2HSD17B10ICMTCYP2C9 | |
| SCHEMBL8485828 | 0.77 | DPP4 (0.53) | HSD11B1HSD17B10EPHX2CYP2C8 | |
| SCHEMBL31650239 | 0.76 | POLB (0.48) | HSD11B1HTTFFAR1 | |
| SCHEMBL436643 | 0.76 | DPP4 (0.52) | HSD11B1HSD17B10EPHX2CYP2C8 | |
| SCHEMBL16341923 | 0.75 | HSD11B1 (0.38) | HSD11B1EPHX2CYP2C8CYP2C9 | |
| SCHEMBL435334 | 0.75 | HSD11B1 (0.71) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356113-B1 | HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS | BAYER IP GMBH (DE) | 2015-01-07 | — | — | EP | disclosed |
| EP-2356113-A1 | HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010054763-A1 | HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-05-20 | — | — | WO | disclosed |