SCHEMBL233079

SCHEMBL233079

CO[Si](OC)(OC)C(CC#N)Cc1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.42
PBRM1 Q86U86 1/20 0.40
CTSS P25774 7/20 0.38
CTSL P07711 6/20 0.38
CTSB P07858 4/20 0.38
TAAR1 Q96RJ0 3/20 0.37
SLC6A2 P23975 2/20 0.37
MAOA P21397 1/20 0.37
SLC6A4 P31645 1/20 0.37
SLC6A3 Q01959 1/20 0.37
SIGMAR1 Q99720 1/20 0.37
CYP2A6 P11509 1/20 0.37
ADORA2A P29274 1/20 0.37
ADORA1 P30542 1/20 0.37
CTSK P43235 4/20 0.37
ANPEP P15144 1/20 0.36
EPHX1 P07099 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL233931 0.83 MAOB (0.41) MAOBPBRM1CTSSCTSLCTSB
SCHEMBL21296087 0.81 MAOB (0.36) MAOBCTSSTAAR1SLC6A2MAOA
SCHEMBL6332012 0.80 TRPA1 (0.43) TAAR1SLC6A2MAOASLC6A4SLC6A3
SCHEMBL2111677 0.79 ANPEP (0.46) TAAR1SLC6A2MAOASLC6A4SLC6A3
SCHEMBL485619 0.79 TAAR1 (0.39) TAAR1SLC6A2MAOASLC6A4SLC6A3
SCHEMBL27769938 0.79 TAAR1 (0.39) TAAR1SLC6A2MAOASLC6A4SLC6A3
SCHEMBL6324755 0.78 PBRM1 (0.33) MAOBPBRM1CTSSCTSLCTSB
SCHEMBL614445 0.76 ALDH1A1 (0.49) TAAR1SLC6A2MAOASLC6A4SLC6A3
SCHEMBL27669064 0.75 MAOB (0.45) MAOBPBRM1CTSSCTSLCTSB
SCHEMBL1730609 0.74 TAAR1 (0.50) TAAR1SLC6A2MAOASLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0987286-B1 Silicone gels and composites from sheet and tube organofunctional siloxane polymers DOW CORNING (US) 2004-07-14 EP claimed
EP-0987286-A2 Silicone gels and composites from sheet and tube organofunctional siloxane polymers DOW CORNING CORPORATION (US) 2000-03-22 EP claimed
US-6013705-A Silicone gels and composites from sheet and tube organofunctional siloxane polymers DOW CORNING CORPORATION (US) 2000-01-11 US claimed
EP-0637902-B1 Metallic foil with adhesion promoting layer GOULD ELECTRONICS INC (US) 1999-03-31 EP claimed
CN-1106977-A Metallic foil with adhesion promoting layer COULD ELECTRONICS INC (US) 1995-08-16 CN claimed
EP-0637902-A1 Metallic foil with adhesion promoting layer GOULD ELECTRONICS INC. (US) 1995-02-08 EP claimed
US-8597508-B2 Sol-gel monolithic column with optical window and method of making UNIVERSITY OF SOUTH FLORIDA (US) 2013-12-03 US disclosed
EP-1037511-B1 Surface treatment of copper to prevent microcracking in flexible circuits JX NIPPON MINING & METALS CORP (JP) 2012-07-18 EP disclosed
US-20120000850-A1 SOL-GEL MONOLITHIC COLUMN WITH OPTICAL WINDOW AND METHOD OF MAKING UNIVERSITY OF SOUTH FLORIDA (US) 2012-01-05 US disclosed
US-7947174-B2 Sol-gel monolithic column with optical window and method of making UNIVERSITY OF SOUTH FLORIDA (US) 2011-05-24 US disclosed
US-7749607-B2 Film derrived from a conductive sol-gel aqueous emulsion containing emulsifiers, organofunctional silanes, and conductive metals and/or metal oxides; mirror finish smooth surface; powder coating for heat sensitive and/or flammable objects NORTHERN ILLINOIS UNIVERSITY (US) 2010-07-06 US disclosed
US-20100112208-A1 Titania-Based Coating for Capillary Microextraction MALIK ABDUL 2010-05-06 US disclosed
US-7622191-B2 also called in tube solid-phase microextraction; inorganic-organic hybrid coating of titania-polydimethylsiloxane; preconcentrates sample for high pressure liquid chromatography analysis; pH stability, retains extraction performance even after NaOH treatment UNIVERSITY OF SOUTH FLORIDA (US) 2009-11-24 US disclosed
EP-0637902-B1 Metallic foil with adhesion promoting layer GOULD ELECTRONICS INC (US) 1999-03-31 EP disclosed
US-5885436-A Adhesion enhancement for metal foil GOULD ELECTRONICS INC. (US) 1999-03-23 US disclosed
EP-0896502-A1 Method of treating metal foil for enhancing adhesion Gould Electronics Inc. (US) 1999-02-10 EP disclosed
US-5622782-A USEFUL IN MANUFACTURE OF PRINTED CIRCUIT BOARDS GOULD INC. (US) 1997-04-22 US disclosed
CN-1106977-A Metallic foil with adhesion promoting layer COULD ELECTRONICS INC (US) 1995-08-16 CN disclosed
EP-0637902-A1 Metallic foil with adhesion promoting layer GOULD ELECTRONICS INC. (US) 1995-02-08 EP disclosed
WO-1992005433-A1 CONTINUOUS POSITIVE CHARGE CAPILLARY COLUMNS USED IN CAPILLARY ELECTROPHORESIS KERR ROBERT (FR) 1992-04-02 WO disclosed