⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15368857 | 0.75 | FBP1 (0.40) | — | |
| SCHEMBL21184288 | 0.75 | FBP1 (0.40) | — | |
| SCHEMBL21184290 | 0.75 | FBP1 (0.40) | — | |
| SCHEMBL23797577 | 0.72 | — | — | |
| SCHEMBL21184378 | 0.70 | FBP1 (0.33) | — | |
| SCHEMBL21184380 | 0.70 | FBP1 (0.33) | — | |
| SCHEMBL19940051 | 0.69 | — | — | |
| SCHEMBL24500006 | 0.69 | CA2 (0.38) | — | |
| SCHEMBL12899516 | 0.69 | — | — | |
| SCHEMBL13941424 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10995335-B2 | RNAi agents and compositions for inhibiting expression of angiopoietin-like 3 (ANGPTL3), and methods of use | Arrowhead Pharmaceuticals, Inc. (US) | 2021-05-04 | — | — | US | disclosed |