Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.60 |
| ▸ | DRD2 | P14416 | 6/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 5/20 | 0.47 |
| ▸ | DRD1 | P21728 | 3/20 | 0.47 |
| ▸ | DRD5 | P21918 | 3/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | PRCP | P42785 | 1/20 | 0.46 |
| ▸ | EBP | Q15125 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23251067 | 0.91 | DRD3 (0.49) | DRD3DRD2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13452526 | 0.89 | DRD3 (0.58) | DRD3DRD2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24809401 | 0.84 | DRD2 (0.40) | DRD3DRD2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15502380 | 0.81 | QDPR (0.50) | DRD3DRD2SLC6A2SLC6A3KCNH2 | |
| SCHEMBL12925934 | 0.81 | SLC6A2 (0.55) | DRD3DRD2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7634263 | 0.81 | HDAC4 (0.47) | DRD3DRD2 | |
| SCHEMBL19122810 | 0.80 | DRD3 (0.69) | DRD3DRD2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11888476 | 0.80 | DRD3 (0.69) | DRD3DRD2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5667630 | 0.79 | KMO (0.49) | DRD3DRD2 | |
| SCHEMBL24310013 | 0.79 | DRD3 (0.70) | DRD3DRD2DRD4DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021087096-A1 | P53 MODULATORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-05-06 | — | — | WO | disclosed |