Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.30 |
| ▸ | C1S | P09871 | 1/20 | 0.30 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21060996 | 0.67 | DEGS1 (0.39) | KMT2AMEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL21757292 | 0.67 | KMT2A (0.39) | KMT2AMEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL28045077 | 0.65 | F2 (0.39) | KMT2AMEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL18962596 | 0.65 | F2 (0.39) | KMT2AMEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL13570230 | 0.65 | ALDH1A1 (0.33) | KMT2AMEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL23320218 | 0.65 | PARP1 (0.37) | KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL20866944 | 0.63 | BLM (0.41) | KMT2AMEN1ALDH1A1MAPK1PRSS1 | |
| SCHEMBL31512537 | 0.62 | KMT2A (0.44) | KMT2AMEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL28174232 | 0.62 | TDP1 (0.50) | KMT2AMEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL10078738 | 0.62 | ALDH1A1 (0.43) | KMT2AMEN1ALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021087144-A1 | THERAPEUTIC METHODS USING VADADUSTAT | AKEBIA THERAPEUTICS, INC. (US) | 2021-05-06 | — | — | WO | disclosed |