Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 15/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formamide SCHEMBL23320449 | 0.85 | ALDH1A1 (0.43) | NAMPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL23320440 | 0.75 | NAMPT (0.63) | NAMPTHTTROCK2ROCK1 | |
| SCHEMBL23320357 | 0.72 | NAMPT (0.56) | NAMPTHTTROCK2ROCK1 | |
| Formamide SCHEMBL23320445 | 0.71 | NAMPT (0.52) | NAMPTHTT | |
| SCHEMBL23320353 | 0.71 | NAMPT (0.60) | NAMPTHTTROCK2ROCK1 | |
| Formamide SCHEMBL23320434 | 0.71 | ELANE (0.39) | MAPK14MAPK1 | |
| SCHEMBL11616834 | 0.69 | HTT (1.00) | NAMPTHTTROCK2ROCK1 | |
| SCHEMBL23320389 | 0.69 | NAMPT (1.00) | NAMPTHTTROCK2ROCK1 | |
| SCHEMBL23320372 | 0.69 | NAMPT (0.60) | NAMPTHTTROCK2ROCK1 | |
| Formamide SCHEMBL23320496 | 0.67 | NAMPT (0.55) | NAMPTHTTROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | claimed |
| CN-112654608-A | Condensed ring compounds having urea structure | 桑福德伯纳姆普利斯医学发现研究所 | 2021-04-13 | — | — | CN | claimed |
| CN-112654608-B | Fused ring compound having urea structure | 桑福德伯纳姆普利斯医学发现研究所 | 2024-05-07 | — | — | CN | disclosed |
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | disclosed |
| CN-112654608-A | Condensed ring compounds having urea structure | 桑福德伯纳姆普利斯医学发现研究所 | 2021-04-13 | — | — | CN | disclosed |