Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.68 |
| ▸ | POLB | P06746 | 7/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 8/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.67 |
| ▸ | PPARG | P37231 | 1/20 | 0.67 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.67 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.65 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23320381 | 0.92 | NAMPT (1.00) | NAMPTALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL24042577 | 0.82 | NAMPT (0.70) | NAMPTALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL2246191 | 0.81 | ALDH1A1 (0.76) | ALDH1A1POLBSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL23320402 | 0.81 | NAMPT (0.81) | NAMPTALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL2245519 | 0.81 | ALDH1A1 (1.00) | ALDH1A1POLBSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL28637363 | 0.78 | NAMPT (0.64) | NAMPTALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL30943187 | 0.78 | NAMPT (0.75) | NAMPTALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL23320431 | 0.78 | NAMPT (0.75) | NAMPTALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL2246316 | 0.78 | ALDH1A1 (0.87) | ALDH1A1POLBSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL19307177 | 0.77 | ALDH1A1 (0.74) | ALDH1A1POLBSMN1; SMN2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11918568-B2 | Fused ring compound having urea structure | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-03-05 | — | — | US | claimed |
| US-20210361636-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | DAIICHI SANKYO COMPANY LIMITED (JP) | 2021-11-25 | — | — | US | claimed |
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | claimed |
| US-12263159-B2 | Fused ring compound having urea structure | Sanford Burnham Prebys Medical Discovery Institute (US) | 2025-04-01 | — | — | US | disclosed |
| US-20240285597-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | DAIICHI SANKYO COMPANY LIMITED (JP) | 2024-08-29 | — | — | US | disclosed |
| CN-112654608-B | Fused ring compound having urea structure | 桑福德伯纳姆普利斯医学发现研究所 | 2024-05-07 | — | — | CN | disclosed |
| US-11918568-B2 | Fused ring compound having urea structure | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-03-05 | — | — | US | disclosed |
| EP-3818053-B1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST (US) | 2023-03-29 | — | — | EP | disclosed |
| US-20210361636-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | DAIICHI SANKYO COMPANY LIMITED (JP) | 2021-11-25 | — | — | US | disclosed |
| US-20210361636-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | DAIICHI SANKYO COMPANY LIMITED (JP) | 2021-11-25 | — | — | US | disclosed |
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12263159-B2 | Fused ring compound having urea structure | NAMPT, NME4, NDUFAB1 | NAMPT 1/4885ALDH1A1 1608/4885POLB 1959/4885 |
| US-20210361636-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | NAMPT, NME4, ABAT | NAMPT 1/4885ALDH1A1 1751/4885POLB 1799/4885 |
| US-11918568-B2 | Fused ring compound having urea structure | NAMPT, NME4, ABAT | NAMPT 1/4885ALDH1A1 1751/4885POLB 1799/4885 |
| US-20240285597-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | NAMPT, NME4, NDUFAB1 | NAMPT 1/4885ALDH1A1 1608/4885POLB 1959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.