Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.57 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 3/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23320481 | 0.90 | NAMPT (0.57) | ROCK2ROCK1L3MBTL1NAMPT | |
| SCHEMBL23320539 | 0.82 | PRMT3 (0.52) | ROCK2ROCK1PRMT3KDM4ENAMPT | |
| SCHEMBL23320504 | 0.81 | NAMPT (0.54) | ROCK2ROCK1NAMPT | |
| SCHEMBL23320463 | 0.81 | PRMT3 (0.45) | ROCK2ROCK1PRMT3KDM4ENAMPT | |
| SCHEMBL23320508 | 0.81 | ALDH1A1 (0.50) | ROCK2ROCK1L3MBTL1NAMPTMAPK1 | |
| SCHEMBL24042574 | 0.77 | NAMPT (0.54) | ROCK2ROCK1NAMPT | |
| SCHEMBL30943269 | 0.77 | NAMPT (0.54) | ROCK2ROCK1NAMPT | |
| SCHEMBL23320580 | 0.76 | NAMPT (0.59) | ROCK2ROCK1NAMPTMEN1KMT2A | |
| SCHEMBL30943163 | 0.76 | NAMPT (0.59) | ROCK2ROCK1NAMPTMEN1KMT2A | |
| SCHEMBL23320509 | 0.74 | NAMPT (0.81) | ROCK2ROCK1PRMT3KDM4ENAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | claimed |
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | disclosed |