Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23320481 | 0.82 | NAMPT (0.57) | L3MBTL1ROCK2ROCK1NAMPTHTT | |
| SCHEMBL23320506 | 0.81 | ROCK2 (0.57) | L3MBTL1ROCK2ROCK1NAMPTMAPK1 | |
| SCHEMBL23320504 | 0.76 | NAMPT (0.54) | ROCK2ROCK1NAMPTHTT | |
| SCHEMBL4519247 | 0.74 | HSD17B10 (0.70) | ALDH1A1TSHRROCK2ROCK1NAMPT | |
| SCHEMBL4531077 | 0.74 | HSD17B10 (0.70) | ALDH1A1TSHRROCK2ROCK1NAMPT | |
| SCHEMBL11615932 | 0.73 | HSD17B10 (0.79) | ALDH1A1TSHRROCK2ROCK1NAMPT | |
| SCHEMBL24042574 | 0.72 | NAMPT (0.54) | ROCK2ROCK1NAMPTHTT | |
| SCHEMBL30943269 | 0.72 | NAMPT (0.54) | ROCK2ROCK1NAMPTHTT | |
| SCHEMBL10065474 | 0.72 | L3MBTL1 (0.55) | L3MBTL1 | |
| SCHEMBL23320400 | 0.71 | NAMPT (0.66) | ALDH1A1TSHRROCK2ROCK1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | claimed |
| EP-3818053-A1 | FUSED RING COMPOUND HAVING UREA STRUCTURE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-05-12 | — | — | EP | disclosed |