Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 3/20 | 0.40 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.40 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8138050 | 0.87 | HTR7 (0.48) | HTR7DRD2DRD1HTR2AHTR2C | |
| SCHEMBL1543064 | 0.83 | HTR7 (0.51) | HTR7DRD2DRD1HTR2AHTR2C | |
| SCHEMBL2201343 | 0.81 | HTR7 (0.59) | HTR7DRD2DRD1HTR2AHTR2C | |
| SCHEMBL2337261 | 0.80 | MAPT (0.42) | IDO1ALDH1A1POLBBLMNQO2 | |
| SCHEMBL9651965 | 0.79 | HTR7 (0.54) | HTR7DRD2DRD1HTR2AHTR2C | |
| SCHEMBL28573199 | 0.78 | IDO1 (0.64) | IDO1ALDH1A1POLBBLMTDO2 | |
| SCHEMBL18854022 | 0.78 | PGR (0.56) | HTR7DRD2DRD1HTR2AHTR2C | |
| SCHEMBL2988221 | 0.78 | PGR (0.56) | HTR7DRD2DRD1HTR2AHTR2C | |
| SCHEMBL10505472 | 0.78 | IDO1 (0.39) | IDO1ALDH1A1POLBBLMNQO2 | |
| SCHEMBL14996404 | 0.76 | HTR7 (0.54) | HTR7DRD2DRD1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2533645-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100373-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-08-18 | — | — | WO | disclosed |