Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NQO2 | P16083 | 3/20 | 0.41 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.41 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10505472 | 0.84 | IDO1 (0.39) | MAPTTP53LMNANQO2CDYL2 | |
| SCHEMBL2332233 | 0.80 | HTR7 (0.46) | TP53LMNANQO2CDYL2CDYL | |
| SCHEMBL2056355 | 0.76 | SMN1; SMN2 (0.42) | MAPTTP53LMNANQO2PGR | |
| SCHEMBL28573199 | 0.76 | IDO1 (0.64) | MAPTIDO1POLBALDH1A1BLM | |
| SCHEMBL12727796 | 0.74 | PGR (0.50) | MAPTTP53LMNAPGRPOLB | |
| SCHEMBL29956445 | 0.74 | SMN1; SMN2 (0.40) | MAPTTP53LMNAPGRPOLB | |
| SCHEMBL13698188 | 0.71 | PGR (0.51) | MAPTTP53LMNANQO2CDYL2 | |
| SCHEMBL18898645 | 0.71 | MAOB (0.51) | MAPTTP53LMNAPGRALDH1A1 | |
| SCHEMBL22419352 | 0.71 | SMN1; SMN2 (0.40) | MAPTTP53LMNANQO2PGR | |
| SCHEMBL14484522 | 0.70 | NQO2 (0.44) | MAPTTP53NQO2CDYL2CDYL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2533645-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100373-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-08-18 | — | — | WO | disclosed |