SCHEMBL2332478

SCHEMBL2332478

CC(c1ccnc(C(N)=NO)c1)C(F)(F)F

nearest known ligand 0.32

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.32
NTRK1 P04629 2/20 0.30
PIM1 P11309 2/20 0.30
DEGS1 O15121 1/20 0.30
CHEK1 O14757 1/20 0.30
CDK2 P24941 1/20 0.30
CSNK2A1 P68400 1/20 0.30
PLG P00747 1/20 0.30
PLAU P00749 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13028405 1.00 NPSR1 (0.32) NPSR1NTRK1PIM1DEGS1CHEK1
SCHEMBL28548823 0.82 KMT2A (0.38) DEGS1
SCHEMBL13847046 0.82 DEGS1 (0.32) DEGS1PLGPLAU
SCHEMBL2333826 0.82 NPSR1 (0.33) NPSR1NTRK1PIM1PLAU
SCHEMBL13028378 0.82 NPSR1 (0.33) NPSR1NTRK1PIM1PLAU
SCHEMBL13028372 0.78 NPSR1 (0.38) NPSR1
SCHEMBL2337531 0.78 NPSR1 (0.38) NPSR1
SCHEMBL13028346 0.76 CNR2 (0.34) NPSR1PLAU
SCHEMBL2335265 0.76 CNR2 (0.34) NPSR1PLAU
SCHEMBL12446917 0.73 NOS3 (0.50) NPSR1PLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8318776-B2 Pyridine compound, pesticidal composition and method of controlling pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-11-27 US disclosed
EP-2215086-B1 PYRIDINE COMPOUND, PESTICIDAL COMPOSITION AND METHOD OF CONTROLLING PEST SUMITOMO CHEMICAL CO (JP) 2011-08-24 EP disclosed
US-20100286148-A1 PYRIDINE COMPOUND, PESTICIDAL COMPOSITION AND METHOD OF CONTROLLING PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-11-11 US disclosed
EP-2215086-A1 PYRIDINE COMPOUND, PESTICIDAL COMPOSITION AND METHOD OF CONTROLLING PEST Sumitomo Chemical Company, Limited (JP) 2010-08-11 EP disclosed
WO-2009066786-A1 PYRIDINE COMPOUND, PESTICIDAL COMPOSITION AND METHOD OF CONTROLLING PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-05-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100286148-A1 PYRIDINE COMPOUND, PESTICIDAL COMPOSITION AND METHOD OF CONTROLLING PEST C5, PRDX1, PLPBP NPSR1 1849/4885NTRK1 3936/4885PIM1 4334/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.