Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | CES2 | O00748 | 4/20 | 0.32 |
| ▸ | CES1 | P23141 | 4/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29800159 | 1.00 | ALDH1A1 (0.45) | ALDH1A1ALOX15PLAUELANEKEAP1 | |
| SCHEMBL591163 | 0.84 | ALDH1A1 (0.43) | ALDH1A1ALOX15PLAUELANEKEAP1 | |
| SCHEMBL1190815 | 0.83 | ALOX15 (0.37) | ALDH1A1ALOX15HPGDMAPTTSHR | |
| SCHEMBL28525271 | 0.83 | ALDH1A1 (0.54) | ALDH1A1ALOX15PLAUELANEKEAP1 | |
| SCHEMBL21623381 | 0.79 | CA12 (0.39) | ALDH1A1ALOX15 | |
| SCHEMBL500029 | 0.79 | SMN1; SMN2 (0.50) | KEAP1NFE2L2DGAT1TSHRSMN1; SMN2 | |
| SCHEMBL11819619 | 0.78 | CA12 (0.38) | ALDH1A1ALOX15HPGDMAPTTSHR | |
| SCHEMBL29470949 | 0.78 | ALDH1A1 (0.50) | ALDH1A1ALOX15PLAUELANEKEAP1 | |
| SCHEMBL457385 | 0.78 | ALDH1A1 (0.50) | ALDH1A1ALOX15PLAUELANEKEAP1 | |
| SCHEMBL24710385 | 0.78 | ALDH1A1 (0.54) | ALDH1A1ALOX15KEAP1NFE2L2DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12509436-B2 | Benzamide derivatives as cGAS-sting pathway agonists | BARUCH S. BLUMBERG INSTITUTE (US) | 2025-12-30 | — | — | US | disclosed |
| CN-118175911-A | Organic photoelectric detector based on full condensed ring small molecule electron acceptor and application thereof | 中国科学院长春应用化学研究所 | 2024-06-11 | — | — | CN | disclosed |
| CN-113583019-B | ADA' DA type full condensed ring micromolecule and preparation method and application thereof | 中国科学院长春应用化学研究所 | 2022-07-19 | — | — | CN | disclosed |
| US-20210347752-A1 | BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS | BARUCH S. BLUMBERG INSTITUTE | 2021-11-11 | — | — | US | disclosed |
| CN-113583019-A | ADA' DA type full condensed ring micromolecule and preparation method and application thereof | 中国科学院长春应用化学研究所 | 2021-11-02 | — | — | CN | disclosed |
| CN-112888688-A | Benzamide derivatives as CGAS-STING pathway agonists | 巴鲁克斯布伦博格研究所 | 2021-06-01 | — | — | CN | disclosed |
| WO-2020072492-A1 | BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS | BARUCH S. BLUMBERG INSTITUTE (US) | 2020-04-09 | — | — | WO | disclosed |
| EP-2356110-B1 | QUINAZOLINAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-01-06 | — | — | EP | disclosed |
| EP-2356110-B1 | QUINAZOLINAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-01-06 | — | — | EP | disclosed |
| US-8546565-B2 | Quinazolinamide derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2013-10-01 | — | — | US | disclosed |
| US-20110245225-A1 | QUINAZOLINAMIDE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTING (DE) | 2011-10-06 | — | — | US | disclosed |
| US-20110245225-A1 | QUINAZOLINAMIDE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTING (DE) | 2011-10-06 | — | — | US | disclosed |
| US-20110245225-A1 | QUINAZOLINAMIDE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTING (DE) | 2011-10-06 | — | — | US | disclosed |
| EP-2356110-A1 | QUINAZOLINAMIDE DERIVATIVES | Merck Patent GmbH (DE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010066324-A1 | QUINAZOLINAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-06-17 | — | — | WO | disclosed |
| WO-2010066324-A1 | QUINAZOLINAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-06-17 | — | — | WO | disclosed |
| US-4786649-A | ANTISEPTICS | OTSUKA PHARMACEUTICAL COMPANY LIMITED (JP) | 1988-11-22 | — | — | US | disclosed |
| US-4684648-A | Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds and compositions thereof | OTSUKA PHARMACEUTICAL COMPANY LIMITED (JP) | 1987-08-04 | — | — | US | disclosed |
| EP-0228035-A2 | Antimicrobial 1-thienyl-4-oxoquinoline-3-carboxylix acid compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-07-08 | — | — | EP | disclosed |
| EP-0181521-A1 | Antimicrobial 1-substituted Phenyl-4-oxoquinoline-3-carboxylic acid compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12509436-B2 | Benzamide derivatives as cGAS-sting pathway agonists | STING1, CGAS, IFNAR1 | ALDH1A1 4236/4885ALOX15 4386/4885PLAU 4794/4885 |
| US-20110245225-A1 | QUINAZOLINAMIDE DERIVATIVES | HSP90AB1, HSP90AA1, HSP90B1 | ALDH1A1 2061/4885ALOX15 4734/4885PLAU 4858/4885 |
| US-20210347752-A1 | BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS | STING1, CGAS, MAVS | ALDH1A1 3145/4885ALOX15 3541/4885PLAU 4489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.