Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23321396 | 0.86 | LMNA (0.82) | MAPTLMNASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL23326278 | 0.85 | PTGS2 (0.61) | MAPTLMNASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL1657522 | 0.84 | MAPT (0.87) | MAPTLMNASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL29583869 | 0.84 | MAPT (0.87) | MAPTLMNASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL14735692 | 0.84 | GBA1 (0.69) | MAPTLMNASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL14735802 | 0.83 | LMNA (0.81) | MAPTLMNASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL11812589 | 0.79 | LMNA (0.94) | MAPTLMNASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL11615257 | 0.78 | LMNA (0.66) | MAPTLMNASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL8908286 | 0.78 | CTSS (0.72) | MAPTLMNASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL22737374 | 0.77 | MAPT (0.62) | MAPTLMNASMN1; SMN2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368184-A1 | PIKfyve Inhibitors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2024-11-07 | — | — | US | disclosed |
| US-12030896-B2 | PIKfyve inhibitors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2024-07-09 | — | — | US | disclosed |
| US-12030896-B2 | PIKfyve inhibitors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2024-07-09 | — | — | US | disclosed |
| US-12030896-B2 | PIKfyve inhibitors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2024-07-09 | — | — | US | disclosed |
| US-20210139505-A1 | PIKfyve Inhibitors | Sanford Burnham Prebys Medical Discovery Institute | 2021-05-13 | — | — | US | disclosed |
| US-20210139505-A1 | PIKfyve Inhibitors | Sanford Burnham Prebys Medical Discovery Institute | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030896-B2 | PIKfyve inhibitors | PIKFYVE, PIP4K2B, PIP4K2A | MAPT 3914/4885LMNA 3750/4885SMN1; SMN2 2618/4885 |
| US-20210139505-A1 | PIKfyve Inhibitors | PIKFYVE, PIP4K2B, PIP4K2A | MAPT 3914/4885LMNA 3750/4885SMN1; SMN2 2618/4885 |
| US-20240368184-A1 | PIKfyve Inhibitors | PIKFYVE, PIP4K2B, PIP4K2A | MAPT 3914/4885LMNA 3750/4885SMN1; SMN2 2618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.