Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29798282 | 1.00 | MAPT (0.42) | MAPTHRH4HRH3SMN1; SMN2CYP1A2 | |
| SCHEMBL2233920 | 0.84 | SMN1; SMN2 (0.41) | HRH4HRH3SMN1; SMN2CXCR4GABRP | |
| SCHEMBL28478495 | 0.80 | OPRM1 (0.40) | MAPTSMN1; SMN2CXCR4S1PR2S1PR4 | |
| SCHEMBL21412738 | 0.77 | KDM4E (0.43) | SMN1; SMN2CXCR4LMNAS1PR2S1PR1 | |
| SCHEMBL10863389 | 0.77 | MC4R (0.46) | CXCR4GABRPGABRDGABRA1GABRB1 | |
| Trifluoroacetic Acid SCHEMBL29798318 | 0.76 | GABRP (0.42) | SMN1; SMN2CYP2C19LMNAGABRPGABRD | |
| Trifluoroacetic Acid SCHEMBL23327049 | 0.76 | GABRP (0.42) | SMN1; SMN2CYP2C19LMNAGABRPGABRD | |
| SCHEMBL29798459 | 0.73 | MAPT (0.43) | MAPTGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL23327044 | 0.73 | HCAR3 (0.46) | HRH4HRH3SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL29798534 | 0.73 | HCAR3 (0.46) | HRH4HRH3SMN1; SMN2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210139429-A1 | COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE | ELEX BIOTECH, INC. (US) | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139429-A1 | COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE | RYR2, RYR1, CACNA1F | MAPT 341/4885HRH4 1054/4885HRH3 1637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.