Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA5A | P35218 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930766 | 0.90 | LMNA (0.42) | TRPV1KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL23327453 | 0.90 | LMNA (0.42) | TRPV1KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL23351083 | 0.86 | LMNA (0.47) | TRPV1KMT2ACNR1MAPK1FPR2 | |
| SCHEMBL23327703 | 0.83 | KDM4E (0.36) | TRPV1KMT2AMEN1MAPK1SMN1; SMN2 | |
| SCHEMBL23327537 | 0.82 | NR3C2 (0.38) | KMT2AMEN1NPC1SMN1; SMN2HTT | |
| SCHEMBL23327500 | 0.77 | ALDH1A1 (0.43) | KMT2ANPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL23351205 | 0.76 | ALDH1A1 (0.35) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26098304 | 0.74 | PTPN1 (0.49) | KMT2AMEN1SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL21811192 | 0.70 | KDM4E (0.44) | NPC1RAB9ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL23327454 | 0.69 | MAPT (0.42) | NPC1MAPK1ALDH1A1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348478-A1 | TYK2 PSEUDOKINASE LIGANDS | VENTYX BIOSCIENCES, INC. | 2023-11-02 | — | — | US | disclosed |
| US-11753411-B2 | Substituted pyrazolo[1,5-a]pyrimidines as TYK2 pseudokinase ligands | VENTYX BIOSCIENCES, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| EP-4054581-A1 | TYK2 PSEUDOKINASE LIGANDS | Ventyx Biosciences, Inc. (US) | 2022-09-14 | — | — | EP | disclosed |
| US-20210139486-A1 | TYK2 PSEUDOKINASE LIGANDS | VENTYX BIOSCIENCES, INC. | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11753411-B2 | Substituted pyrazolo[1,5-a]pyrimidines as TYK2 pseudokinase ligands | TYK2, JAK1, JAK2 | TRPV1 4454/4885KMT2A 819/4885MEN1 3085/4885 |
| US-20230348478-A1 | TYK2 PSEUDOKINASE LIGANDS | TYK2, JAK2, PTK2B | TRPV1 4340/4885KMT2A 901/4885MEN1 3354/4885 |
| US-20210139486-A1 | TYK2 PSEUDOKINASE LIGANDS | TYK2, JAK2, PTK2B | TRPV1 4340/4885KMT2A 901/4885MEN1 3354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.