SCHEMBL23328486

SCHEMBL23328486

N#Cc1ccc(N(c2ccc(-c3ccc4sc5ccccc5c4c3)cc2)c2ccc(C#N)c3ccccc23)c2ccccc12

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 1/20 0.34
SLC22A12 Q96S37 1/20 0.34
MAPT P10636 3/20 0.33
ALDH1A1 P00352 2/20 0.33
KDM4E B2RXH2 1/20 0.33
GAA P10253 1/20 0.33
CYP1A2 P05177 1/20 0.32
IMPDH2 P12268 1/20 0.32
IMPDH1 P20839 1/20 0.32
DHODH Q02127 1/20 0.32
HPGD P15428 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
PIM3 Q86V86 1/20 0.30
CYP11B1 P15538 1/20 0.30
CYP11B2 P19099 1/20 0.30
AR P10275 1/20 0.30
PRSS12 P56730 1/20 0.30
SLC9A1 P19634 1/20 0.30
PTGIR P43119 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23328502 0.90 GPR3 (0.38) GPR3SLC22A12MAPTALDH1A1KDM4E
SCHEMBL23328508 0.88 SLC22A12 (0.38) GPR3SLC22A12MAPTALDH1A1CYP1A2
SCHEMBL25544533 0.86 GPR3 (0.37) GPR3SLC22A12MAPTALDH1A1KDM4E
SCHEMBL23328482 0.86 GPR3 (0.37) GPR3SLC22A12MAPTALDH1A1KDM4E
SCHEMBL25543481 0.85 GPR3 (0.36) GPR3SLC22A12MAPTALDH1A1KDM4E
SCHEMBL25544698 0.82 GPR3 (0.36) GPR3SLC22A12MAPTALDH1A1KDM4E
SCHEMBL23328698 0.81 SLC22A12 (0.39) GPR3SLC22A12MAPTALDH1A1CYP1A2
SCHEMBL23328487 0.81 ALOX5 (0.44) SLC22A12MAPTALDH1A1KDM4EGAA
SCHEMBL23328483 0.81 PRSS12 (0.41) GPR3MAPTALDH1A1HPGDRAB9A
SCHEMBL23328465 0.81 PRSS12 (0.41) GPR3MAPTALDH1A1HPGDRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021085817-A2 TERTIARY AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME 주식회사 랩토 2021-05-06 WO disclosed