Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6184366 | 0.95 | SLC6A3 (0.59) | SLC6A3SLC6A4SLC6A2DPP4SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6185182 | 0.93 | SLC6A3 (0.58) | SLC6A3SLC6A4SLC6A2DPP4SIGMAR1 | |
| SCHEMBL2339483 | 0.93 | SLC6A4 (0.47) | SLC6A3SLC6A4SLC6A2DPP4SIGMAR1 | |
| SCHEMBL34463017 | 0.93 | SLC6A4 (0.47) | SLC6A3SLC6A4SLC6A2DPP4SIGMAR1 | |
| SCHEMBL11310169 | 0.78 | SIGMAR1 (0.44) | SLC6A3SLC6A4SLC6A2SIGMAR1HTT | |
| SCHEMBL30040158 | 0.78 | HTT (0.64) | SIGMAR1HTTALDH1A1MEN1KMT2A | |
| SCHEMBL9355631 | 0.77 | SIGMAR1 (0.43) | SLC6A3SLC6A4SLC6A2SIGMAR1HTT | |
| SCHEMBL14902529 | 0.76 | CYP3A4 (0.48) | ALDH1A1 | |
| SCHEMBL10612019 | 0.73 | CNR1 (0.43) | SLC6A3SLC6A4SLC6A2SIGMAR1HTT | |
| SCHEMBL29965651 | 0.73 | SIGMAR1 (0.72) | SIGMAR1HTTCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358716-B1 | INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP) | MERCK SHARP & DOHME (US) | 2016-01-06 | — | — | EP | disclosed |
| US-8815875-B2 | Inhibitors of fatty acid binding protein (FABP) | MERCK SHARP & DOHME CORP. (US) | 2014-08-26 | — | — | US | disclosed |
| US-20110237575-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP) | MERCK SHARP & DOHME LLC | 2011-09-29 | — | — | US | disclosed |
| EP-2358716-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP) | Schering Corporation (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010056631-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP) | SCHERING CORPORATION (US) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237575-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP) | FABP4, FABP1, FABP3 | SLC6A3 3939/4885SLC6A4 3042/4885SLC6A2 3859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.