Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 3/20 | 0.54 |
| ▸ | FCER2 | P06734 | 4/20 | 0.48 |
| ▸ | HPGDS | O60760 | 3/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24942260 | 1.00 | MMP1 (0.54) | MMP1FCER2HPGDSPPARGMMP9 | |
| SCHEMBL23332003 | 0.85 | EGFR (0.49) | MMP8ATMCYP2C19ALDH1A1THRB | |
| SCHEMBL23331979 | 0.85 | EGFR (0.49) | MMP8ATMCYP2C19ALDH1A1THRB | |
| SCHEMBL8374049 | 0.82 | FCER2 (0.50) | MMP1FCER2HPGDSPPARGMMP9 | |
| SCHEMBL19584939 | 0.81 | MMP9 (0.56) | MMP1FCER2HPGDSMMP9MMP8 | |
| SCHEMBL24925106 | 0.79 | MMP1 (0.48) | MMP1FCER2HPGDSCAPN1CYP2C19 | |
| SCHEMBL3616167 | 0.79 | MMP1 (0.55) | MMP1FCER2HPGDSPPARGATM | |
| SCHEMBL3616169 | 0.79 | MMP1 (0.55) | MMP1FCER2HPGDSPPARGATM | |
| SCHEMBL3107407 | 0.79 | FCER2 (0.52) | MMP1FCER2HPGDSPPARGMMP9 | |
| SCHEMBL24942198 | 0.78 | MMP1 (0.47) | MMP1FCER2PPARGATMCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230025922-A1 | USE OF ITACONATE AND ITS DERIVATIVES/ANALOGUES TO INDUCE HAIR GROWTH | THE JOHNS HOPKINS UNIVERSTY | 2023-01-26 | — | — | US | disclosed |
| US-20230028516-A1 | PRODRUGS OF ITACONATE AND METHYL ITACONATE | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR V.V.I. (CZ) | 2023-01-26 | — | — | US | disclosed |
| CN-115052588-A | Prodrugs of itaconate and methyl itaconate | 约翰霍普金斯大学 | 2022-09-13 | — | — | CN | disclosed |
| WO-2021087083-A1 | USE OF ITACONATE AND ITS DERIVATIVES/ANALOGUES TO INDUCE HAIR GROWTH | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-05-06 | — | — | WO | disclosed |
| WO-2021087082-A1 | PRODRUGS OF ITACONATE AND METHYL ITACONATE | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230025922-A1 | USE OF ITACONATE AND ITS DERIVATIVES/ANALOGUES TO INDUCE HAIR GROWTH | LRBA, HADHA, IMPDH1 | MMP1 126/4885FCER2 4023/4885HPGDS 136/4885 |
| US-20230028516-A1 | PRODRUGS OF ITACONATE AND METHYL ITACONATE | HADHA, IMPDH1, CYP27A1 | MMP1 645/4885FCER2 3630/4885HPGDS 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.