Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3470686 | 0.87 | MEN1 (0.63) | KMT2AMEN1NPC1SMN1; SMN2KDM4E | |
| SCHEMBL3470463 | 0.84 | MEN1 (0.77) | KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3470521 | 0.73 | ALDH1A1 (0.52) | KMT2AMEN1NPC1SMN1; SMN2KDM4E | |
| SCHEMBL15214217 | 0.72 | MEN1 (0.47) | KMT2AMEN1NPC1SMN1; SMN2RAB9A | |
| Oxalic Acid SCHEMBL3470130 | 0.71 | KMT2A (0.63) | KMT2AMEN1ALDH1A1POLBFLT1 | |
| SCHEMBL3470125 | 0.66 | KMT2A (0.63) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13485752 | 0.65 | HPGD (0.59) | KMT2AMEN1NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7706279 | 0.65 | HPGD (0.59) | KMT2AMEN1NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1520599 | 0.64 | MEN1 (0.65) | KMT2AMEN1NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7208739 | 0.64 | RAB9A (0.59) | KMT2AMEN1NPC1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011097600-A1 | SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY | THE WISTAR INSTITUTE (US) | 2011-08-11 | — | — | WO | disclosed |