SCHEMBL7208739

SCHEMBL7208739

Cc1ccc(C(=O)c2ccccc2Cl)c(Cl)c1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.59
KMT2A Q03164 4/20 0.54
MEN1 O00255 2/20 0.54
LMNA P02545 2/20 0.54
KDM4E B2RXH2 1/20 0.54
RECQL P46063 1/20 0.53
MAPK13 O15264 4/20 0.51
MAPK12 P53778 4/20 0.51
MAPK11 Q15759 4/20 0.51
MAPK14 Q16539 4/20 0.51
CES2 O00748 1/20 0.50
CES1 P23141 1/20 0.50
NPC1 O15118 2/20 0.49
PKM P14618 1/20 0.49
ALDH1A1 P00352 3/20 0.48
HPGD P15428 2/20 0.47
GAA P10253 2/20 0.46
MAPT P10636 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23070442 0.90 HPGD (0.53) RAB9AKMT2AMEN1MAPK13MAPK12
SCHEMBL8459090 0.89 RAB9A (0.53) RAB9AKMT2AMEN1LMNAKDM4E
SCHEMBL29826380 0.88 AKR1C3 (0.57) RAB9AKMT2AMEN1MAPK13MAPK12
SCHEMBL144223 0.88 KMT2A (0.57) RAB9AKMT2AMEN1LMNAKDM4E
SCHEMBL256822 0.86 TP53 (0.48) RAB9AKMT2AMEN1LMNAMAPK13
SCHEMBL9712419 0.86 KMT2A (0.52) RAB9AKMT2AMEN1LMNAKDM4E
SCHEMBL21550137 0.86 RAB9A (0.50) RAB9AKMT2AMEN1LMNAKDM4E
SCHEMBL9717031 0.86 ABCB1 (0.56) RAB9AKMT2AMEN1LMNAKDM4E
SCHEMBL12303221 0.85 KMT2A (0.51) RAB9AKMT2AMEN1LMNAKDM4E
SCHEMBL9654244 0.84 RECQL (0.71) RAB9AKMT2AMEN1LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1208571-B1 CABLE, IN PARTICULAR FOR TRANSPORT OR DISTRIBUTION OF ELECTRICAL ENERGY AND INSULATING COMPOSITION PIRELLI (IT) 2003-10-01 EP disclosed
US-20020164480-A1 Cable, in particular for transport or distribution of electrical energy and insulating composition PRYSMIAN CAVI E SISTEMI ENERGIA S.R.L. (IT) 2002-11-07 US disclosed
EP-1208571-A1 CABLE, IN PARTICULAR FOR TRANSPORT OR DISTRIBUTION OF ELECTRICAL ENERGY AND INSULATING COMPOSITION PIRELLI CAVI E SISTEMI S.p.A. (IT) 2002-05-29 EP disclosed
WO-2001008166-A1 CABLE, IN PARTICULAR FOR TRANSPORT OR DISTRIBUTION OF ELECTRICAL ENERGY AND INSULATING COMPOSITION PIRELLI CAVI E SISTEMI S.P.A. (IT) 2001-02-01 WO disclosed
US-4006248-A HYPOLIPIDEMIC SANDOZ, INC. (US) 1977-02-01 US disclosed