Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 12/20 | 0.43 |
| ▸ | HTR1B | P28222 | 12/20 | 0.43 |
| ▸ | HTR1A | P08908 | 11/20 | 0.43 |
| ▸ | HTR6 | P50406 | 9/20 | 0.43 |
| ▸ | HTR2A | P28223 | 7/20 | 0.43 |
| ▸ | HTR2C | P28335 | 6/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14733338 | 0.84 | AR (0.47) | ARKDM4EGAAMAPTMAPK1 | |
| SCHEMBL14733333 | 0.77 | AR (0.50) | ARKDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL2325963 | 0.77 | MAPT (0.55) | DRD2DRD3KDM4EMAPTHTT | |
| SCHEMBL2328336 | 0.76 | DRD2 (0.47) | DRD2DRD3KDM4EGAAMAPT | |
| SCHEMBL2325995 | 0.76 | HTR2C (0.55) | DRD2DRD3HTR1DHTR1BHTR1A | |
| SCHEMBL2330397 | 0.75 | HTR6 (0.56) | DRD2DRD3KDM4EGAAMAPK1 | |
| SCHEMBL2329746 | 0.75 | MAPT (0.56) | DRD2DRD3KDM4EMAPTHTR1D | |
| SCHEMBL2329980 | 0.74 | DRD2 (0.45) | DRD2DRD3KDM4EGAAMAPT | |
| SCHEMBL2327923 | 0.74 | MAPT (0.52) | DRD2DRD3KDM4EMAPTHTT | |
| SCHEMBL14717225 | 0.74 | DRD2 (0.57) | DRD2DRD3KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130053372-A1 | 5-HT RECEPTOR MODULATORS | CAMBRIDGE ENTERPRISE LIMITED | 2013-02-28 | — | — | US | claimed |
| US-20130053372-A1 | 5-HT RECEPTOR MODULATORS | CAMBRIDGE ENTERPRISE LIMITED | 2013-02-28 | — | — | US | disclosed |
| US-20130053372-A1 | 5-HT RECEPTOR MODULATORS | CAMBRIDGE ENTERPRISE LIMITED | 2013-02-28 | — | — | US | disclosed |
| EP-2536711-A1 | 5-HT RECEPTOR MODULATORS | Cambridge Enterprise Limited (GB) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011098776-A1 | 5-HT RECEPTOR MODULATORS | CAMBRIDGE ENTERPRISE LIMITED (GB) | 2011-08-18 | — | — | WO | disclosed |
| WO-2011098776-A1 | 5-HT RECEPTOR MODULATORS | CAMBRIDGE ENTERPRISE LIMITED (GB) | 2011-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053372-A1 | 5-HT RECEPTOR MODULATORS | HTR1B, HTR5A, HTR1A | DRD2 176/4885DRD3 510/4885AR 799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.