SCHEMBL2333767

SCHEMBL2333767

COC(=O)CC(c1cc(F)cc(Br)c1)C(C#N)c1cccc(F)c1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 5/20 0.40
HDAC4 P56524 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC5 Q9UQL6 1/20 0.38
KMT2A Q03164 2/20 0.36
CYP2C19 P33261 2/20 0.35
CYP2C9 P11712 1/20 0.35
TSHR P16473 1/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
CYP2D6 P10635 1/20 0.35
MAPT P10636 2/20 0.34
POLB P06746 1/20 0.34
MAPK1 P28482 1/20 0.34
PGR P06401 1/20 0.34
AR P10275 1/20 0.34
ALDH1A1 P00352 1/20 0.33
HTT P42858 1/20 0.33
CNR2 P34972 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10179071 0.92 KCNA5 (0.40) KCNA5KMT2AMEN1MAPTPOLB
SCHEMBL10695128 0.90 KCNA5 (0.41) KCNA5HDAC4HDAC7HDAC5KMT2A
SCHEMBL10181046 0.89 ALDH1A1 (0.42) KCNA5KMT2ACYP2C19CYP2C9KDM4E
SCHEMBL10695685 0.88 KCNA5 (0.45) KCNA5HDAC4HDAC7HDAC5KMT2A
SCHEMBL10451133 0.86 KMT2A (0.49) KCNA5HDAC4HDAC7HDAC5KMT2A
SCHEMBL2329370 0.86 HDAC4 (0.38) HDAC4HDAC7HDAC5ALDH1A1HTT
SCHEMBL2330078 0.86 POLB (0.35) HDAC4HDAC7HDAC5KMT2AMAPT
SCHEMBL10451128 0.84 KMT2A (0.46) KCNA5HDAC4HDAC7HDAC5KMT2A
SCHEMBL10699742 0.83 PGR (0.43) KCNA5HDAC4HDAC7HDAC5KMT2A
SCHEMBL9681946 0.83 OPRM1 (0.41) KCNA5HDAC4HDAC7HDAC5KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011098417-A1 SUBSTITUTED CYANOBUTYRATES HAVING HERBICIDAL ACTION BASF SE (DE) 2011-08-18 WO disclosed