Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 7/20 | 0.35 |
| ▸ | DRD3 | P35462 | 5/20 | 0.35 |
| ▸ | DRD1 | P21728 | 4/20 | 0.35 |
| ▸ | DRD5 | P21918 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.32 |
| ▸ | ESR1 | P03372 | 4/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9573469 | 0.84 | DRD2 (0.37) | PBRM1DRD2DRD3DRD1DRD5 | |
| SCHEMBL29458622 | 0.76 | ADRA2A (0.39) | — | |
| SCHEMBL9573156 | 0.76 | HTR2A (0.38) | — | |
| SCHEMBL29991918 | 0.76 | HTR2A (0.38) | — | |
| SCHEMBL7659749 | 0.76 | MEN1 (0.34) | DRD3DRD1CA2MAOA | |
| SCHEMBL4724433 | 0.76 | ADRA2A (0.34) | — | |
| SCHEMBL30782257 | 0.76 | TRPA1 (0.45) | — | |
| SCHEMBL9572969 | 0.76 | ADRA2A (0.39) | — | |
| SCHEMBL5190684 | 0.75 | ADCY6 (0.37) | MAOA | |
| Hydrochloric Acid SCHEMBL11658196 | 0.74 | ADRA2A (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109776414-A | A kind of Bcl-2 protein inhibitor and its preparation method and application | 山东大学 | 2019-05-21 | — | — | CN | claimed |
| EP-3819305-A1 | AMIDE COMPOUND HAVING BET PROTEOLYSIS-INDUCING ACTION AND MEDICINAL APPLICATION THEREOF | Mitsubishi Tanabe Pharma Corporation (JP) | 2021-05-12 | — | — | EP | disclosed |
| CN-110461829-A | Substituted isoquinilone derivatives as immunomodulator | BRISTOL MYERS SQUIBB CO | 2019-11-15 | — | — | CN | disclosed |
| CN-110352188-A | Fluoro allylamine derivatives and application thereof | 四川科伦博泰生物医药股份有限公司 | 2019-10-18 | — | — | CN | disclosed |
| CN-105431422-B | Isoindoline or isoquinoline compounds, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2019-08-30 | — | — | CN | disclosed |
| CN-109790125-A | TETRAHYDROISOQUINOLINE KAPPA OPIOID ANTAGONISTS | 研究三角协会 | 2019-05-21 | — | — | CN | disclosed |
| CN-109776414-A | A kind of Bcl-2 protein inhibitor and its preparation method and application | 山东大学 | 2019-05-21 | — | — | CN | disclosed |
| CN-109456324-A | New isoindoline or isoquinoline compound, preparation method and the Pharmaceutical composition containing them | 法国施维雅药厂 | 2019-03-12 | — | — | CN | disclosed |
| CN-107873031-A | Benzoxazinone derivatives and analogs thereof as modulators of TNF activity | UCB生物制药私人有限公司 | 2018-04-03 | — | — | CN | disclosed |
| CN-103450220-B | Nitroimidazole compound and application thereof in pharmacy | 上海阳帆医药科技有限公司 | 2017-02-08 | — | — | CN | disclosed |
| CN-105524045-A | Tetracyclic anaplastic lymphoma kinase inhibitor | KBP BIOSCIENCES CO LTD | 2016-04-27 | — | — | CN | disclosed |
| CN-103880827-A | Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin | ALBANY MOLECULAR RES INC | 2014-06-25 | — | — | CN | disclosed |
| CN-101663278-A | Compounds and compositions as modulators of GPR119 activity | IRM LLC | 2010-03-03 | — | — | CN | disclosed |
| CN-101119969-A | Aryl and heteroaryl substituted tetrahydroisoquinolines and their use to block reuptake of norepinephrine, dopamine, and serotonin | AMR TECHNOLOGY INC (US) | 2008-02-06 | — | — | CN | disclosed |