Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 16/20 | 0.58 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.47 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.47 |
| ▸ | ITGAL | P20701 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23355184 | 1.00 | CAPN1 (0.58) | CAPN1CTSLCTSBITGB2ICAM1 | |
| SCHEMBL23355176 | 0.90 | ITGB2 (0.59) | CAPN1CTSLCTSBITGB2ICAM1 | |
| SCHEMBL23355175 | 0.90 | ITGB2 (0.59) | CAPN1CTSLCTSBITGB2ICAM1 | |
| SCHEMBL24008795 | 0.82 | CA2 (0.57) | CAPN1CTSLCTSBCTSS | |
| SCHEMBL24008798 | 0.81 | CAPN1 (0.52) | CAPN1CTSLCTSBITGB2ICAM1 | |
| SCHEMBL24009788 | 0.81 | L3MBTL1 (0.63) | CAPN1CTSLITGB2ICAM1ITGAL | |
| SCHEMBL29961883 | 0.81 | HPGDS (0.57) | CAPN1CTSLCTSB | |
| SCHEMBL24008816 | 0.81 | HPGDS (0.57) | CAPN1CTSLCTSB | |
| SCHEMBL24008794 | 0.80 | ITGA4 (0.62) | CAPN1CTSLITGB2ICAM1ITGAL | |
| SCHEMBL29961792 | 0.80 | CAPN1 (0.58) | CAPN1ITGB2ICAM1ITGALL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820864-A1 | METHODS OF TREATING LIVER FIBROSIS USING CALPAIN INHIBITORS | Blade Therapeutics, Inc. (US) | 2021-05-19 | — | — | EP | disclosed |