Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 3/20 | 0.41 |
| ▸ | PGK2 | P07205 | 3/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | MMP12 | P39900 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ACP3 | P15309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23363937 | 0.80 | MAPT (0.36) | ALDH1A1L3MBTL1 | |
| SCHEMBL17773615 | 0.79 | ALDH1A1 (0.34) | ALDH1A1LMNARAB9AL3MBTL1 | |
| SCHEMBL23363997 | 0.73 | PGK1 (0.40) | PGK1PGK2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL28652447 | 0.72 | ALDH1A1 (0.32) | ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL29794494 | 0.71 | CCNT1 (0.35) | — | |
| SCHEMBL28652446 | 0.71 | PDCD1LG2 (0.30) | — | |
| SCHEMBL23363806 | 0.70 | PGK1 (0.40) | PGK1PGK2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL25227000 | 0.68 | HTR2A (0.35) | — | |
| SCHEMBL3045991 | 0.67 | PGK1 (0.52) | PGK1PGK2MMP2MMP9MMP12 | |
| SCHEMBL29206809 | 0.67 | ALDH1A1 (0.39) | ALDH1A1LMNARAB9AL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4058435-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2022-09-21 | — | — | EP | disclosed |
| EP-3847154-A1 | CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS | F. Hoffmann-La Roche AG (CH) | 2021-07-14 | — | — | EP | disclosed |
| US-20210188775-A1 | CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS | GENENTECH, INC. (US) | 2021-06-24 | — | — | US | disclosed |
| WO-2021097110-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2021-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188775-A1 | CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS | TEAD2, TEAD1, SULT2A1 | PGK1 2286/4885PGK2 1963/4885GRIN2D 970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.