Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30225613 | 0.89 | ACHE (0.49) | CYP3A4MAPTGAASMN1; SMN2CRHBP | |
| SCHEMBL23842242 | 0.89 | ACHE (0.49) | CYP3A4MAPTGAASMN1; SMN2CRHBP | |
| SCHEMBL10645877 | 0.82 | CYP3A4 (0.62) | CYP3A4MAPTGAASMN1; SMN2CRHBP | |
| SCHEMBL24795 | 0.81 | CYP3A4 (0.52) | CYP3A4MAPTGAASMN1; SMN2CRHBP | |
| Hydrochloric Acid SCHEMBL30081995 | 0.80 | CYP3A4 (0.50) | CYP3A4MAPTGAASMN1; SMN2CRHBP | |
| SCHEMBL13506283 | 0.77 | PDE3B (0.55) | GAAPDE3BPDE3ASRCACHE | |
| SCHEMBL6585554 | 0.74 | CYP3A4 (0.71) | CYP3A4MAPTGAASMN1; SMN2KMT2A | |
| SCHEMBL30133714 | 0.74 | CHRNB2 (0.37) | CYP3A4MAPTGAAPDE3BPDE3A | |
| SCHEMBL24127411 | 0.74 | CHRNB2 (0.37) | CYP3A4MAPTGAAPDE3BPDE3A | |
| SCHEMBL4571013 | 0.73 | CYP3A4 (1.00) | CYP3A4MAPTGAASMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021097075-A1 | SUBSTITUTED ISOINDOLONYL 2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-05-20 | — | — | WO | disclosed |