Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28021992 | 0.81 | LMNA (0.68) | LMNARAB9AALDH1A1HPGDHTT | |
| SCHEMBL14229370 | 0.79 | TSHR (0.51) | LMNARAB9AALDH1A1NOTUMTSHR | |
| SCHEMBL2335054 | 0.77 | KDM1A (0.48) | RAB9ANOTUMNPC1 | |
| SCHEMBL20899628 | 0.75 | BRD4 (0.49) | LMNARAB9AALDH1A1HPGDNOTUM | |
| SCHEMBL29449730 | 0.74 | ALDH1A1 (0.71) | LMNARAB9AALDH1A1HPGDNOTUM | |
| SCHEMBL789554 | 0.74 | ALDH1A1 (0.71) | LMNARAB9AALDH1A1HPGDNOTUM | |
| Hydrochloric Acid SCHEMBL10741975 | 0.73 | ALDH1A1 (0.69) | LMNARAB9AALDH1A1HPGDNOTUM | |
| SCHEMBL16844669 | 0.71 | SETD7 (0.37) | LMNAALDH1A1HTTTSHRTP53 | |
| SCHEMBL7003872 | 0.69 | NOTUM (0.73) | LMNARAB9AALDH1A1HTTNOTUM | |
| SCHEMBL31562020 | 0.69 | LMNA (0.66) | LMNARAB9AALDH1A1HTTNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356094-A1 | NOVEL PHENYL AMIDE OR PYRIDIL AMIDE DERIVATIVES AND THEIR USE AS GPBAR1 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010049302-A1 | NOVEL PHENYL AMIDE OR PYRIDIL AMIDE DERIVATIVES AND THEIR USE AS GPBAR1 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-05-06 | — | — | WO | disclosed |