Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL842907 | 0.85 | HPGD (0.64) | LMNARAB9AHTTNOTUMMEN1 | |
| SCHEMBL9956661 | 0.84 | LMNA (0.58) | LMNARAB9AHTTNOTUMMEN1 | |
| SCHEMBL68594 | 0.84 | NOTUM (0.72) | LMNARAB9AHTTNOTUMALDH1A1 | |
| SCHEMBL31562020 | 0.83 | LMNA (0.66) | LMNARAB9AHTTNOTUMMEN1 | |
| SCHEMBL7003872 | 0.81 | NOTUM (0.73) | LMNARAB9AHTTNOTUMMEN1 | |
| SCHEMBL2337155 | 0.81 | LMNA (0.48) | LMNARAB9AHTTNOTUMMEN1 | |
| SCHEMBL10869086 | 0.80 | LMNA (0.55) | LMNARAB9AHTTNOTUMMEN1 | |
| SCHEMBL608410 | 0.78 | NOTUM (0.54) | LMNARAB9AHTTNOTUMMEN1 | |
| SCHEMBL983021 | 0.78 | RAB9A (0.69) | LMNARAB9AHTTNOTUMMEN1 | |
| SCHEMBL23705411 | 0.77 | LMNA (0.45) | LMNARAB9AHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115698035-A | Inhibitors of norovirus and coronavirus replication | 共晶制药公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-110840847-B | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-107438593-B | Therapeutic compounds and uses thereof | 基因泰克公司 | 2020-10-30 | — | — | CN | disclosed |
| CN-111671751-A | Pharmaceutical compositions for treating CFTR-mediated diseases | 沃泰克斯药物股份有限公司 | 2020-09-18 | — | — | CN | disclosed |
| CN-106163517-B | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2020-08-14 | — | — | CN | disclosed |
| CN-105848657-B | Methods of making pharmaceutical compositions for treating CFTR mediated diseases | 沃泰克斯药物股份有限公司 | 2020-05-22 | — | — | CN | disclosed |
| CN-110840847-A | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2020-02-28 | — | — | CN | disclosed |
| CN-106163517-A | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2016-11-23 | — | — | CN | disclosed |
| CN-104869982-A | Pharmaceutical compositions for treating CFTR-mediated diseases | VERTEX PHARMA | 2015-08-26 | — | — | CN | disclosed |