Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.43 |
| ▸ | SOAT1 | P35610 | 5/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.41 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.41 |
| ▸ | PPARD | Q03181 | 4/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | FABP1 | P07148 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2338544 | 0.94 | L3MBTL1 (0.35) | DGAT1SOAT1LPAR1LPAR2LPAR3 | |
| SCHEMBL2335596 | 0.93 | DGAT1 (0.44) | DGAT1SOAT1LPAR1LPAR2LPAR3 | |
| SCHEMBL2336523 | 0.91 | LPAR1 (0.41) | DGAT1SOAT1LPAR1LPAR2LPAR3 | |
| SCHEMBL2338262 | 0.89 | LPAR1 (0.50) | DGAT1SOAT1LPAR1LPAR2LPAR3 | |
| SCHEMBL3714465 | 0.88 | LPAR1 (0.45) | DGAT1LPAR1LPAR2LPAR3NR1H4 | |
| SCHEMBL3712288 | 0.88 | PPARD (0.39) | LPAR1LPAR2LPAR3NR1H4PPARD | |
| SCHEMBL1246465 | 0.88 | NR1H4 (0.45) | DGAT1SOAT1NR1H4PPARDTP53 | |
| SCHEMBL3702333 | 0.88 | LPAR1 (0.44) | DGAT1SOAT1LPAR1LPAR2LPAR3 | |
| SCHEMBL2338127 | 0.88 | LPAR1 (0.44) | DGAT1SOAT1LPAR1LPAR2LPAR3 | |
| SCHEMBL3704161 | 0.87 | LPAR1 (0.47) | DGAT1SOAT1LPAR1LPAR2LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| EP-2358688-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010077883-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |