Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.43 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | FABP1 | P07148 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245358 | 0.90 | NR1H4 (0.42) | NR1H4GPBAR1SCN9AFABP1PPARD | |
| SCHEMBL1246467 | 0.88 | NR1H4 (0.43) | NR1H4GPBAR1SCN9AFABP1PPARD | |
| SCHEMBL1245176 | 0.88 | NR1H4 (0.40) | NR1H4GPBAR1SCN9AFABP1PPARD | |
| SCHEMBL2337556 | 0.88 | DGAT1 (0.43) | NR1H4DGAT1SOAT1FABP1PPARD | |
| SCHEMBL1246476 | 0.87 | NR1H4 (0.42) | NR1H4DGAT1GPBAR1FABP1PPARD | |
| SCHEMBL1247108 | 0.87 | SCN9A (0.40) | NR1H4GPBAR1SCN9APPARD | |
| SCHEMBL1246477 | 0.86 | NR1H4 (0.42) | NR1H4GPBAR1FABP1PPARDALDH1A1 | |
| SCHEMBL1245270 | 0.84 | KDM4E (0.44) | NR1H4DGAT1GPBAR1SCN9APPARD | |
| SCHEMBL1245335 | 0.84 | NR1H4 (0.50) | NR1H4FABP1PPARDMAPT | |
| SCHEMBL1246346 | 0.84 | SCN9A (0.38) | NR1H4GPBAR1SCN9APPARDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |