Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.30 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.30 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.30 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.30 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.30 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3269723 | 0.88 | CA1 (0.37) | CA1CA12CA2CA9ALDH1A1 | |
| SCHEMBL8682327 | 0.85 | KDM4C (0.39) | CA1CA12CA2CA9ALDH1A1 | |
| SCHEMBL27750796 | 0.81 | CA1 (0.42) | CA1CA12CA2CA9ALDH1A1 | |
| SCHEMBL4269382 | 0.79 | USP2 (0.43) | CA1CA12CA2CA9ALDH1A1 | |
| SCHEMBL4719766 | 0.79 | CA1 (0.41) | CA1CA12CA2CA9ALDH1A1 | |
| SCHEMBL5198515 | 0.79 | CA1 (0.41) | CA1CA12CA2CA9ALDH1A1 | |
| SCHEMBL2332570 | 0.78 | CA1 (0.56) | CA1CA12CA2CA9ALDH1A1 | |
| SCHEMBL20561644 | 0.77 | ALDH1A1 (0.38) | CA1CA12CA2CA9ALDH1A1 | |
| SCHEMBL19543361 | 0.77 | CA1 (0.39) | CA1CA12CA2CA9ALDH1A1 | |
| SCHEMBL6546010 | 0.77 | CA1 (0.39) | CA1CA12CA2CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11160785-B2 | Methods and compositions for improving cognitive function | AGENEBIO INC. (US) | 2021-11-02 | — | — | US | disclosed |
| US-20180015109-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY | 2018-01-18 | — | — | US | disclosed |
| US-20160271108-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | AGENEBIO, INC. | 2016-09-22 | — | — | US | disclosed |
| EP-2533645-B1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | UNIV JOHNS HOPKINS (US) | 2016-07-27 | — | — | EP | disclosed |
| EP-2968220-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | Agenebio, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014144801-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | AGENEBIO INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| EP-2533645-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2012-12-19 | — | — | EP | disclosed |
| US-20110212928-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-09-01 | — | — | US | disclosed |
| WO-2011100373-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-08-18 | — | — | WO | disclosed |
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |
| US-20050124642-A1 | (1-Indanone)-(1,2,3,6-tetrahydropyridine) compounds | EISAI CO., LTD. (JP) | 2005-06-09 | — | — | US | disclosed |
| US-20050107432-A1 | Sigma receptor binder containing indanone derivative | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-05-19 | — | — | US | disclosed |
| EP-1468684-A1 | SIGMA RECEPTOR BINDER CONTAINING INDANONE DERIVATIVE | Eisai Co., Ltd. (JP) | 2004-10-20 | — | — | EP | disclosed |
| US-6706741-B2 | ALZHEIMER*S DISEASE | EISAI CO., LTD. (JP) | 2004-03-16 | — | — | US | disclosed |
| US-20030069289-A1 | Acetylcholinesterase inhibitors containing 1-benzyl-pyridinium salts | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2003-04-10 | — | — | US | disclosed |
| EP-1285656-A1 | ACETYLCHOLINESTERASE INHIBITORS CONTAINING 1-BENZYL- PYRIDINIUM SALTS | Eisai Co., Ltd. (JP) | 2003-02-26 | — | — | EP | disclosed |
| US-5843983-A | Diphenylethane compounds containing a saturated heterocyclic group, their preparation, and their therapeutic use | SANKYO COMPANY, LIMITED (JP) | 1998-12-01 | — | — | US | disclosed |
| US-5523407-A | ACYLCOENZYME A:CHOLESTEROL ACYLTRANSFERASE INHIBITORS, FOR TREATING OR PREVENTING HYPERCHOLESTEROLEMIA, ATHEROSCLEROSIS, CARDIOVASCULAR DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-06-04 | — | — | US | disclosed |
| US-5362742-A | Acyl CoA: cholesterol acyltransferase | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-11-08 | — | — | US | disclosed |
| EP-0505565-B1 | QUINOLINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-04-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160271108-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE2, BACE1, GRIN2A | CA1 828/4885CA12 483/4885CA2 3139/4885 |
| US-20030069289-A1 | Acetylcholinesterase inhibitors containing 1-benzyl-pyridinium salts | ACHE, CHRM1, BCHE | CA1 38/4885CA12 848/4885CA2 53/4885 |
| US-11160785-B2 | Methods and compositions for improving cognitive function | BACE2, BACE1, GRIN2A | CA1 828/4885CA12 483/4885CA2 3139/4885 |
| US-20180015109-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE1, BACE2, ACHE | CA1 350/4885CA12 825/4885CA2 1638/4885 |
| US-20110212928-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE1, BACE2, ACHE | CA1 350/4885CA12 825/4885CA2 1638/4885 |
| US-20050107432-A1 | Sigma receptor binder containing indanone derivative | SIGMAR1, OPRK1, TMEM97 | CA1 3745/4885CA12 4569/4885CA2 2717/4885 |
| US-20050124642-A1 | (1-Indanone)-(1,2,3,6-tetrahydropyridine) compounds | SIGMAR1, CHRM1, ACHE | CA1 1288/4885CA12 4358/4885CA2 1340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.