Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | POLQ | O75417 | 1/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 5/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23362902 | 0.82 | SLC22A12 (0.47) | SLC22A12KDM4EALDH1A1MAPTIKBKE | |
| SCHEMBL30168457 | 0.82 | SLC22A12 (0.47) | SLC22A12KDM4EALDH1A1MAPTIKBKE | |
| SCHEMBL16502627 | 0.78 | DGAT2 (0.53) | SLC22A12MAPK8MAPK9MAPK10KDM4E | |
| SCHEMBL3633318 | 0.76 | KDM4E (0.53) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL23376833 | 0.76 | IKBKE (0.51) | SLC22A12KDM4EALDH1A1MAPTIKBKE | |
| SCHEMBL29802386 | 0.76 | KDM4E (0.53) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL8442857 | 0.75 | DGAT2 (0.66) | ALDH1A1DGAT2 | |
| SCHEMBL1586686 | 0.75 | BDKRB1 (0.53) | BDKRB1 | |
| SCHEMBL12588693 | 0.74 | BDKRB1 (0.46) | KDM4EALDH1A1MAPTBDKRB1 | |
| SCHEMBL6240424 | 0.74 | LMNA (0.63) | SLC22A12KDM4EIKBKETBK1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220411378-A1 | SMALL MOLECULES POLYMERASE INHIBITORS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2022-12-29 | — | — | US | disclosed |
| WO-2021096589-A1 | SMALL MOLECULES POLYMERASE INHIBITORS | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2021-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220411378-A1 | SMALL MOLECULES POLYMERASE INHIBITORS | POLRMT, POLR1E, POLR2E | SLC22A12 3844/4885MAPK8 2590/4885MAPK9 2809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.