Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2095077 | 0.86 | KMT2A (0.62) | KMT2AALDH1A1MEN1NLRP3RAB9A | |
| SCHEMBL20560179 | 0.83 | KMT2A (0.43) | PTGS2KMT2AALDH1A1MEN1NLRP3 | |
| SCHEMBL30254352 | 0.80 | L3MBTL1 (0.42) | PTGS2KMT2AALDH1A1MEN1RAB9A | |
| SCHEMBL23885108 | 0.80 | L3MBTL1 (0.42) | PTGS2KMT2AALDH1A1MEN1RAB9A | |
| SCHEMBL20475214 | 0.79 | RAB9A (0.51) | PTGS2KMT2AALDH1A1MEN1NLRP3 | |
| SCHEMBL16176784 | 0.78 | KMT2A (0.50) | KMT2AALDH1A1MEN1NLRP3RAB9A | |
| SCHEMBL23043120 | 0.77 | KMT2A (0.49) | KMT2AALDH1A1NLRP3RAB9ACES2 | |
| SCHEMBL4726032 | 0.77 | HDAC1 (0.56) | KMT2AALDH1A1MEN1NLRP3RAB9A | |
| SCHEMBL15577855 | 0.76 | KMT2A (0.39) | PTGS2KMT2AALDH1A1NLRP3RAB9A | |
| SCHEMBL20560144 | 0.76 | PTGS2 (0.37) | PTGS2KMT2AALDH1A1MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534156-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | OSI Pharmaceuticals, LLC (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100502-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | OSI Pharmaceuticals, LLC (US) | 2011-08-18 | — | — | WO | disclosed |