Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.36 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5792889 | 1.00 | KEAP1 (0.46) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| SCHEMBL7897470 | 1.00 | KEAP1 (0.46) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| Hydrochloric Acid SCHEMBL10638555 | 0.98 | KEAP1 (0.45) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| SCHEMBL7896588 | 0.98 | KCNQ2 (0.44) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| SCHEMBL5792763 | 0.91 | KEAP1 (0.44) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| Hydrochloric Acid SCHEMBL17871814 | 0.90 | KEAP1 (0.42) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| SCHEMBL7900199 | 0.90 | KEAP1 (0.42) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| SCHEMBL5794047 | 0.88 | LMNA (0.42) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| SCHEMBL19665213 | 0.86 | KEAP1 (0.45) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| Hydrochloric Acid SCHEMBL17872072 | 0.85 | KEAP1 (0.44) | KEAP1KCNQ2GAAMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358369-A1 | Process for the preparation of substantially optically pure repaglinide and precursors thereof | Krka Tovarna Zdravil, D.D., Novo Mesto (SI) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010046360-A1 | PROCESS FOR THE PREPARATION OF SUBSTANTIALLY OPTICALLY PURE REPAGLINIDE AND PRECURSORS THEREOF | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2010-04-29 | — | — | WO | disclosed |
| EP-2177221-A1 | Process for the preparation of substantially optically pure Repaglinide and precursors thereof | Krka Tovarna Zdravil, D.D., Novo Mesto (SI) | 2010-04-21 | — | — | EP | disclosed |