Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 5/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794047 | 0.99 | LMNA (0.42) | KEAP1LMNAALDH1A1KDM4EGAA | |
| SCHEMBL5792763 | 0.96 | KEAP1 (0.44) | KEAP1LMNAALDH1A1KDM4EGAA | |
| Hydrochloric Acid SCHEMBL17871814 | 0.94 | KEAP1 (0.42) | KEAP1LMNAALDH1A1KDM4EGAA | |
| SCHEMBL5792889 | 0.90 | KEAP1 (0.46) | KEAP1LMNAALDH1A1GAAMC4R | |
| SCHEMBL7897470 | 0.90 | KEAP1 (0.46) | KEAP1LMNAALDH1A1GAAMC4R | |
| SCHEMBL2339105 | 0.90 | KEAP1 (0.46) | KEAP1LMNAALDH1A1GAAMC4R | |
| Hydrochloric Acid SCHEMBL10638555 | 0.88 | KEAP1 (0.45) | KEAP1LMNAALDH1A1GAAMC4R | |
| SCHEMBL7896588 | 0.88 | KCNQ2 (0.44) | KEAP1ALDH1A1GAAMC4RKCNQ2 | |
| SCHEMBL19665213 | 0.82 | KEAP1 (0.45) | KEAP1GAAMC4RKCNQ2MAPK1 | |
| Hydrochloric Acid SCHEMBL17872072 | 0.81 | KEAP1 (0.44) | KEAP1GAAMC4RKCNQ2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37035-E1 | HYPOGLYCEMIC AGENTS | BOEHRINGER INGELHEIM KG (DE) | 2001-01-30 | — | — | US | disclosed |
| US-6143769-A | ENANTIOMORPH | KARL THOMAE GMBH (DE) | 2000-11-07 | — | — | US | disclosed |
| US-5312924-A | Compounds for lowering blood sugar and effecting metabolism | DR. KARL THOMAE GMBH (DE) | 1994-05-17 | — | — | US | disclosed |
| US-5216167-A | Hypoglycemic agents | DR. KARL THOMAE GMBH (DE) | 1993-06-01 | — | — | US | disclosed |
| EP-0147850-B1 | PHENYLACETIC-ACID DERIVATIVES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1989-06-14 | — | — | EP | disclosed |
| EP-0147850-A2 | Phenylacetic-acid derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1985-07-10 | — | — | EP | disclosed |