Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.36 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5792889 | 1.00 | KEAP1 (0.46) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| SCHEMBL2339105 | 1.00 | KEAP1 (0.46) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| Hydrochloric Acid SCHEMBL10638555 | 0.98 | KEAP1 (0.45) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| SCHEMBL7896588 | 0.98 | KCNQ2 (0.44) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| SCHEMBL5792763 | 0.91 | KEAP1 (0.44) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| Hydrochloric Acid SCHEMBL17871814 | 0.90 | KEAP1 (0.42) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| SCHEMBL7900199 | 0.90 | KEAP1 (0.42) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| SCHEMBL5794047 | 0.88 | LMNA (0.42) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| SCHEMBL19665213 | 0.86 | KEAP1 (0.45) | KEAP1KCNQ2GAAMAPK1NPC1 | |
| Hydrochloric Acid SCHEMBL17872072 | 0.85 | KEAP1 (0.44) | KEAP1KCNQ2GAAMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37035-E1 | HYPOGLYCEMIC AGENTS | BOEHRINGER INGELHEIM KG (DE) | 2001-01-30 | — | — | US | disclosed |
| US-6143769-A | ENANTIOMORPH | KARL THOMAE GMBH (DE) | 2000-11-07 | — | — | US | disclosed |
| US-5312924-A | Compounds for lowering blood sugar and effecting metabolism | DR. KARL THOMAE GMBH (DE) | 1994-05-17 | — | — | US | disclosed |
| US-5216167-A | Hypoglycemic agents | DR. KARL THOMAE GMBH (DE) | 1993-06-01 | — | — | US | disclosed |
| EP-0147850-B1 | PHENYLACETIC-ACID DERIVATIVES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1989-06-14 | — | — | EP | disclosed |
| EP-0147850-A2 | Phenylacetic-acid derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1985-07-10 | — | — | EP | disclosed |